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Titolo:
Effects of fibrogenic mediators on the development of pancreatic fibrosis in a TGF-beta 1 transgenic mouse model
Autore:
Vogelmann, R; Ruf, D; Wagner, M; Adler, G; Menke, A;
Indirizzi:
Univ Ulm, Dept Internal Med 1, D-89081 Ulm, Germany Univ Ulm Ulm GermanyD-89081 , Dept Internal Med 1, D-89081 Ulm, Germany
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
fascicolo: 1, volume: 280, anno: 2001,
pagine: G164 - G172
SICI:
0193-1857(200101)280:1<G164:EOFMOT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; COLLAGEN GENE-EXPRESSION; TRANSFORMING GROWTH-FACTOR-BETA-1; EXTRACELLULAR-MATRIX; STELLATE CELLS; LIVER MYOFIBROBLASTS; RAT PANCREAS; IDENTIFICATION; TISSUE; REGENERATION;
Keywords:
transforming growth factor-beta; connective tissue growth factor; fibroblast growth factor-2; chronic pancreatitis; pancreatic stellate cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Vogelmann, R Univ Ulm, Dept Internal Med 1, Robert Koch Str 8, D-89081 Ulm, Germany Univ Ulm Robert Koch Str 8 Ulm Germany D-89081 Ulm, Germany
Citazione:
R. Vogelmann et al., "Effects of fibrogenic mediators on the development of pancreatic fibrosis in a TGF-beta 1 transgenic mouse model", AM J P-GAST, 280(1), 2001, pp. G164-G172

Abstract

The pancreas morphology of transgenic mice that overexpress transforming growth factor-beta1 (TGF-beta1) in the pancreas resembles partially morphological features of chronic pancreatitis, such as progressive accumulation ofextracellular matrix (ECM). Using this transgenic mouse model, we characterized the composition of pancreatic fibrosis and involved fibrogenic mediators. On day 14 after birth, fibrotic tissue was mainly composed of collagentype I and III. At this time, mRNA levels of TGF-beta1 were increased. On day 70, the ECM composition was expanded by increased deposition of fibronectin, whereas connective tissue growth factor, fibroblast growth factor (FGF)-1, and FGF-2 mRNA expression levels were elevated in addition to TGF-beta1. In parallel, the number of pancreatic stellate cells (PSC) increased over time. In vitro, TGF-beta1 stimulated collagen type I expression but not fibronectin expression in PSC, in contrast to FGF-2, which stimulated both. This confirms that TGF-beta1 mediates pancreatic fibrosis through activation of PSC and deposition of collagen type I and III at early time points. Furthermore, this points to an indirect mechanism in which TGF-beta regulates pancreatic ECM assembly by induction of additional growth factors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 09:28:33