Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Different actions of secretin and Gly-extended secretin predict secretin receptor subtypes
Autore:
Solomon, TE; Varga, G; Zeng, N; Wu, SV; Walsh, JH; Reeve, JR;
Indirizzi:
Dept Vet Affairs Greater Los Angeles Healthcare S, Res Serv 151, CURE Digest Dis Res Ctr, Los Angeles, CA 90073 USA Dept Vet Affairs Greater Los Angeles Healthcare S Los Angeles CA USA 90073 Univ Calif Los Angeles, Sch Med, Div Digest Dis, Los Angeles, CA 90024 USAUniv Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Hungarian Acad Sci, Inst Expt Med, H-1450 Budapest, Hungary Hungarian AcadSci Budapest Hungary H-1450 Med, H-1450 Budapest, Hungary
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
fascicolo: 1, volume: 280, anno: 2001,
pagine: G88 - G94
SICI:
0193-1857(200101)280:1<G88:DAOSAG>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIC-ACID SECRETION; PERFUSED RAT STOMACH; VASOACTIVE-INTESTINAL-PEPTIDE; ADENYLATE-CYCLASE; PANCREATIC-SECRETION; CONSCIOUS RATS; SOMATOSTATIN RELEASE; MOLECULAR-CLONING; CELLS; CHOLECYSTOKININ;
Keywords:
posttranslational processing; receptor specificity; D cells; somatostatin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Solomon, TE Dept Vet Affairs Greater Los Angeles Healthcare S, Res Serv 151, CURE Digest Dis Res Ctr, Bldg 115,Rm 111,11301 Wilshire Blvd, Los Angeles, CA 90073 USA Dept Vet Affairs Greater Los Angeles Healthcare S Bldg 115,Rm 111,11301 Wilshire Blvd Los Angeles CA USA 90073
Citazione:
T.E. Solomon et al., "Different actions of secretin and Gly-extended secretin predict secretin receptor subtypes", AM J P-GAST, 280(1), 2001, pp. G88-G94

Abstract

Only one secretin receptor has been cloned and its properties characterized in native and transfected cells. To test the hypothesis that stimulatory and inhibitory effects of secretin are mediated by different secretin receptor subtypes, pancreatic and gastric secretory responses to secretin and secretin-Gly were determined in rats. Pancreatic fluid secretion was increased equipotently by secretin and secretin-Gly, but secretin was markedly morepotent for inhibition of basal and gastrin-induced acid secretion. In Chinese hamster ovary cells stably transfected with the rat secretin receptor, secretin and secretin-Gly equipotently displaced I-125-labeled secretin (IC50 values 5.3 +/- 0.5 and 6.4 +/- 0.6 nM, respectively). Secretin, but not secretin-Gly, caused release of somatostatin from rat gastric mucosal D cells. Thus the equipotent actions of secretin and secretin-Gly on pancreatic secretion appear to result from equal binding and activation of the pancreatic secretin receptor. Conversely, secretin more potently inhibited gastricacid secretion in vivo, and only secretin released somatostatin from D cells in vitro. These results support the existence of a secretin receptor subtype mediating inhibition of gastric acid secretion that is distinct from the previously characterized pancreatic secretin receptor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 08:13:42