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Titolo:
Intraluminal acid and gastric mucosal integrity: the importance of blood-borne bicarbonate
Autore:
Synnerstad, I; Johansson, M; Nylander, O; Holm, L;
Indirizzi:
Univ Uppsala, Ctr Biomed, Dept Physiol, S-75123 Uppsala, Sweden Univ Uppsala Uppsala Sweden S-75123 ept Physiol, S-75123 Uppsala, Sweden
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
fascicolo: 1, volume: 280, anno: 2001,
pagine: G121 - G129
SICI:
0193-1857(200101)280:1<G121:IAAGMI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; NITRIC-OXIDE; RAT STOMACH; MICROVASCULAR ARCHITECTURE; INTESTINAL PERMEABILITY; AFFERENT NEURONS; LASER-DOPPLER; FLOW; PENTAGASTRIN; PH;
Keywords:
gastric acid; laser-Doppler flowmetry; permeability; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Holm, L Univ Uppsala, Ctr Biomed, Dept Physiol, POB 572, S-75123 Uppsala, Sweden Univ Uppsala POB 572 Uppsala Sweden S-75123 75123 Uppsala, Sweden
Citazione:
I. Synnerstad et al., "Intraluminal acid and gastric mucosal integrity: the importance of blood-borne bicarbonate", AM J P-GAST, 280(1), 2001, pp. G121-G129

Abstract

The acid-secreting gastric mucosa resists intraluminal acid better than the nonsecreting. Here we investigated pH at the epithelial cell surface, mucosal permeability, and blood flow during intraluminal administration of acid (100 mM) in acid-stimulated and nonstimulated gastric corpus mucosae. Surface pH (H+-selective microelectrodes), permeability (clearance of Cr-51-EDTA), and mucosal blood flow (laser-Doppler flowmetry) were studied in Inactin-anesthetized rats. Acid secretion was stimulated with pentagastrin (40 mug.kg(-1).h(-1)) or impromidine (500 mug.kg(-1).h(-1)), or HCO3- (5 mmol.kg(-1).h(-1)) given intravenously. Surface pH was only slightly reduced by intraluminal acid in acid secretion-stimulated or HCO3--treated rats but was substantially lowered in nonstimulated rats. Clearance increased threefold and blood flow increased by approximate to 75% in nonstimulated rats. During stimulated acid secretion or intravenous infusion of HCO3-, clearance wasunchanged and blood flow increased by only approximate to 30% during intraluminal acid. Increased epithelial transport of HCO3- buffering the mucus gel is most probably the explanation for the acid-secreting mucosa being less vulnerable to intraluminal acid than the nonsecreting.

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Documento generato il 05/12/20 alle ore 20:05:15