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Titolo:
Left ventricular hypertrophy as a predictor of coronary heart disease mortality and the effect of hypertension
Autore:
Brown, DW; Giles, WH; Croft, JB;
Indirizzi:
Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 th, Dept Epidemiol, Atlanta, GA 30322 USA Ctr Dis Control & Prevent, Cardiovasc Hlth Branch, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA Ctr Dis Control & Prevent Atlanta GA USA & Hlth Promot, Atlanta, GA USA
Titolo Testata:
AMERICAN HEART JOURNAL
fascicolo: 6, volume: 140, anno: 2000,
pagine: 848 - 856
SICI:
0002-8703(200012)140:6<848:LVHAAP>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATIONAL DEATH INDEX; RISK FACTOR; FOLLOW-UP; MASS; CRITERIA; HEALTH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Giles, WH CDC, Div Adult & Community Hlth, NCCDPHP, Mailstop K-45,4770 Buford Hwy NE, Atlanta, GA 30341 USA CDC Mailstop K-45,4770 Buford Hwy NE Atlanta GA USA 30341 41 USA
Citazione:
D.W. Brown et al., "Left ventricular hypertrophy as a predictor of coronary heart disease mortality and the effect of hypertension", AM HEART J, 140(6), 2000, pp. 848-856

Abstract

Background Although associations between hypertension, left ventricular hypertrophy (LVH), and coronary heart disease (CHD) have been described, it is less clear whether LVH is associated with increased rates of CHD in the absence of hypertension. Methods we examined this association with Cox regression analyses of data from 7924 adults 25 to 74 years of age from the Second National Health and Nutrition Examination Survey (NHANES II) Mortality Study (1976 to 1992). Covariates included age, race, sex, history of cardiovascular diseases and diabetes, cholesterol, body moss index, blood pressure, and smoking. Results During 16.8 follow-up years, there were 462 (26%) deaths from CHD (ICD-9 410-414) and 667 (38%) deaths from diseases of the heart (ICD-9 390-398, 402, 404, 410-414, 415-417, 420-429). LVH prevalence was 13.3 per 1000population. Hypertension prevalence was 29.1%. LVH prevalence was higher among hypertensive adults than among normotensive adults (29.9 vs 6.4 per 1000, P <.001). Persons with LVH were twice as likely to die of CHD (relativerisk, 2.0; 95% confidence interval, 1.2, 3.5) and diseases of the heart (relative risk, 1.9, 95% confidence interval, 1.1, 3.0) after adjustment for hypertension and covariates. In age-adjusted predicted survivor, probability plots for CHD, and diseases of the heart, normotensives with LVH had survival similar to hypertensive adults with LVH and lower survival than normotensive and hypertensive adults with no LVH. Conclusions our results confirm previous findings that the presence of LVHis a strong predictor of future cardiovascular death. Although LVH appearsto be rare among normotensives clinicians should be aware that such individuals may have on increased risk for death similar to that of hypertensive adults with LVH.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 19:00:21