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Titolo:
A pilot study of N-acetyl glucosamine, a nutritional substrate for glycosaminoglycan synthesis, in paediatric chronic inflammatory bowel disease
Autore:
Salvatore, S; Heuschkel, R; Tomlin, S; Davies, SE; Edwards, S; Walker-Smith, JA; French, I; Murch, SH;
Indirizzi:
Royal Free & Univ Coll Sch Med, Univ Dept Paediat Gastroenterol, London, England Royal Free & Univ Coll Sch Med London England oenterol, London, England Royal Free & Univ Coll Sch Med, Dept Pharm, London, England Royal Free & Univ Coll Sch Med London England pt Pharm, London, England Royal Free & Univ Coll Sch Med, Dept Histopathol, London, England Royal Free & Univ Coll Sch Med London England topathol, London, England Royal Free & Univ Coll Sch Med, Dept Radiol, London, England Royal Free & Univ Coll Sch Med London England t Radiol, London, England Glucogen Pharmaceut, Vancouver, BC, Canada Glucogen Pharmaceut Vancouver BC Canada harmaceut, Vancouver, BC, Canada
Titolo Testata:
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
fascicolo: 12, volume: 14, anno: 2000,
pagine: 1567 - 1579
SICI:
0269-2813(200012)14:12<1567:APSONG>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; RESPIRATORY-DISTRESS SYNDROME; INTESTINAL-MUCOSA; SULFATED GLYCOSAMINOGLYCANS; PERITONEAL-DIALYSIS; MATRIX; DEGRADATION; DISRUPTION; CYTOKINES; CHILDREN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Murch, SH Royal Free Hosp NHS Trust, Univ Dept Paediat Gastroenterol, PondSt, London NW3 2QG, England Royal Free Hosp NHS Trust Pond St London England NW3 2QG ngland
Citazione:
S. Salvatore et al., "A pilot study of N-acetyl glucosamine, a nutritional substrate for glycosaminoglycan synthesis, in paediatric chronic inflammatory bowel disease", ALIM PHARM, 14(12), 2000, pp. 1567-1579

Abstract

Background: The breakdown of glycosaminoglycans is an important consequence of inflammation at mucosal surfaces, and inhibition of metalloprotease activity may be effective in treating chronic inflammation. Aim: To report an alternative approach, using the nutriceutical agent N-acetyl glucosamine (GlcNAc), an amino-sugar directly incorporated into glycosaminoglycans and glycoproteins, as a substrate for tissue repair mechanisms. Methods: GlcNAc (total daily dose 3-6 g) was administered orally as adjunct therapy to 12 children with severe treatment-resistant inflammatory boweldisease (10 Crohn's disease, 2 ulcerative colitis). Seven of these children suffered from symptomatic strictures. In addition, similar doses were administered rectally as sole therapy in nine children with distal ulcerative colitis or proctitis resistant to steroids and antibiotics. Where pre- and post-treatment biopsies were available (nine cases), histochemical assessment of epithelial and matrix glycosaminoglycans and GlcNAc residues was made. Findings: Eight of the children given oral GlcNAc showed clear improvement, while four required resection. Of the children with symptomatic Crohn's stricture, only 3 of 7 have required surgery over a mean follow-up of > 2.5 years, and endoscopic or radiological improvement was detected in the others. Rectal administration induced remission in two cases, clear improvement in three and no effect in two. In all cases biopsied there was evidence of histological improvement, and a significant increase in epithelial and lamina propria glycosaminoglycans and intracellular GlcNAc. Conclusions: GlcNAc shows promise as an inexpensive and nontoxic treatmentin chronic inflammatory bowel disease, with a mode of action which is distinct from conventional treatments. It may have the potential to be helpful in stricturing disease. However, controlled trials and an assessment of enteric-release preparations are required to confirm its efficacy and establish indications for use.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:17:57