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Titolo:
Increased distractibility by task-irrelevant sound changes in abstinent alcoholics
Autore:
Ahveninen, J; Jaaskelainen, IP; Pekkonen, E; Hallberg, A; Hietanen, M; Naatanen, R; Schroger, E; Sillanaukee, P;
Indirizzi:
Univ Helsinki, Dept Psychol, Cognit Brain Res Unit, FIN-00014 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00014 it, FIN-00014 Helsinki, Finland Univ Helsinki, Dept Neurol, FIN-00014 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00014 ol, FIN-00014 Helsinki, Finland A Clin Fdn, Jarvenpaa Social Hosp, Jarvenpaa, Finland A Clin Fdn Jarvenpaa Finland Jarvenpaa Social Hosp, Jarvenpaa, Finland Univ Leipzig, Inst Gen Psychol, Leipzig, Germany Univ Leipzig Leipzig Germany eipzig, Inst Gen Psychol, Leipzig, Germany Tampere Univ Hosp, Res Unit, Tampere, Finland Tampere Univ Hosp Tampere Finland Univ Hosp, Res Unit, Tampere, Finland
Titolo Testata:
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
fascicolo: 12, volume: 24, anno: 2000,
pagine: 1850 - 1854
SICI:
0145-6008(200012)24:12<1850:IDBTSC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVENT-RELATED POTENTIALS; MISMATCH NEGATIVITY; BRAIN POTENTIALS; SENSORY MEMORY; FAMILY HISTORY; DEPENDENCE; INPATIENTS; ETHANOL;
Keywords:
alcoholism; EEG; auditory event-related potentials; involuntary attention shifting; mismatch negativity (MMN);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Ahveninen, J Univ Helsinki, Dept Psychol, Cognit Brain Res Unit, POB 13, FIN-00014 Helsinki, Finland Univ Helsinki POB 13 Helsinki Finland FIN-00014nki, Finland
Citazione:
J. Ahveninen et al., "Increased distractibility by task-irrelevant sound changes in abstinent alcoholics", ALC CLIN EX, 24(12), 2000, pp. 1850-1854

Abstract

Background: Chronic alcoholism is accompanied by "frontal" neuropsychological deficits that include an inability to maintain focus of attention. Thismight be associated with pronounced involuntary attention shifting to task-irrelevant stimulus changes and, thereafter, an impaired reorienting to the relevant task. The neural abnormalities that underlie such deficits in alcoholics were explored with event-related potential (ERP) components that disclosed different phases of detection and orienting to stimulus changes. Methods: Twenty consecutive abstinent male alcoholics (DSM-TV) and 20 age-matched male controls (healthy social drinkers) were instructed to discriminate equiprobable 100 and 200 msec tones in a reaction-time task (RT) and to ignore occasional, either slight (7%) or wide (70%), frequency changes (hypothesized to increase RT) during an ERP measurement. Results: In the alcoholics, we found pronounced distractibility, evidencedby a RT lag (p < 0.01) caused by deviants, that correlated (Spearman <rho>= 0.5) with a significantly enhanced (p < 0.01) amplitude of mismatch negativity (MMN) to deviants. Significantly increased RT lag for trials subsequent to deviants (slight p < 0.001, wide p < 0.05) in the alcoholics suggested impaired reorienting to the relevant task. The MMN enhancement also predicted poorer hit rates in the alcoholics (Spearman <rho> = 0.6-0.7). Both the MMN enhancement and pronounced distractibility correlated (Spearman rho = 0.4) with an early onset of alcoholism. Conclusions: Attentional deficits in the abstinent alcoholics were indicated by the increased distractibility by irrelevant sound changes. The MMN enhancement suggested that this reflects impaired neural inhibition of involuntary attention shifting, being most pronounced in early-onset alcoholics.

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Documento generato il 06/04/20 alle ore 07:55:38