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Titolo:
N-methyl-D-aspartate receptor responses are differentially modulated by noncompetitive receptor antagonists and ethanol in inbred long-sleep and short-sleep mice: Behavior and electrophysiology
Autore:
Hanania, T; Negri, CA; Dunwiddie, TV; Zahniser, NR;
Indirizzi:
Univ Colorado, Hlth Sci Ctr, Dept Pharmacol, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 r, Dept Pharmacol, Denver, CO 80262 USA Univ Colorado, Hlth Sci Ctr, Neurosci Program, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 Neurosci Program, Denver, CO 80262 USA Dept Vet Affairs Med Ctr, Denver, CO USA Dept Vet Affairs Med Ctr Denver CO USA t Affairs Med Ctr, Denver, CO USA
Titolo Testata:
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
fascicolo: 12, volume: 24, anno: 2000,
pagine: 1750 - 1758
SICI:
0145-6008(200012)24:12<1750:NRRADM>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED LOCOMOTOR-ACTIVITY; QUANTITATIVE TRAIT LOCI; HIPPOCAMPAL-NEURONS; SEDATIVE-HYPNOTICS; RAT-BRAIN; SLOW MICE; IFENPRODIL; INHIBITION; BINDING; MK-801;
Keywords:
MK-801; radioligand binding; hippocampus; ifenprodil; locomotor stimulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Hanania, T Univ Colorado, Hlth Sci Ctr, Dept Pharmacol, C-236,4200 E 9th Ave, Denver,CO 80262 USA Univ Colorado C-236,4200 E 9th Ave Denver CO USA 80262 0262 USA
Citazione:
T. Hanania et al., "N-methyl-D-aspartate receptor responses are differentially modulated by noncompetitive receptor antagonists and ethanol in inbred long-sleep and short-sleep mice: Behavior and electrophysiology", ALC CLIN EX, 24(12), 2000, pp. 1750-1758

Abstract

Background: Short-sleep (SS) mice exhibit higher locomotor activity than do long-sleep (LS) mice when injected with low doses of ethanol or the noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist MK-801 (dizocilpine). SS mice also have higher densities of brain NMDARs. However, two strains of LS X SS recombinanf inbred (RT) mice also show differential activation to ethanol and MK-801, but have similar numbers of NMDARs. Here we used inbred LS (ILS) and SS (ISS): mice to investigate further the relationship between NMDARs and sensitivity to the stimulant effects of law doses of ethanol. Methods: Open field activity and spontaneous alternations were measured after saline or drug injection. [H-3]MK-801 binding parameters were determined in hippocampus, cortex, striatum, and nucleus accumbens. Extracellular field excitatory postsynaptic potentials (fEPSPs) were recorded in the CA1 region of hippocampal slices. Results: Systemic injection of either ethanol or MK-SOI increased locomotor activity to a greater extent in ISS mice than in ILS mice. The competitive NMDAR antagonist 2-carbaxypiperazin-4-yl-propyl-1-1phosphonic acid (+/-CPP) depressed activity of ILS, but not ISS, mice. No strain differences wereobserved in spontaneous alternations or in the number or affinity of NMDARs in the brain regions examined. Likewise, the magnitudes of hippocampal NMDAR-mediated fEPSPs were similar in ILS and ISS mice and were inhibited to the same extent by a competitive NMDAR antagonist. However, both ethanol and the NMDAR NR2B receptor antagonist ifenprodil inhibited the late component of hippocampal NMDAR fEPSPs to a greater extent in ISS, than in ILS, mice. Conclusions: Differential ethanol- and MK-801-induced behavioral activation in ILS and ISS mice was; not associated with differences in NMDAR number. Nonetheless, pharmacological differences in hippocampal NMDAR responsiveness suggest that ISS mice express NMDARs that have a greater sensitivity to noncompetitive, but not competitive; NMDAR ant agonists. These differences,which. may reflect differences in NMDAR subunit composition, could underlie the differential responsiveness to lbw doses of ethanol in ILS and ISS mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 07:01:07