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Titolo:
Blood microdialysis in pharmacokinetic and drug metabolism studies
Autore:
Verbeeck, RK;
Indirizzi:
Univ Catholique Louvain, Sch Pharm, Pharmacokinet & Drug Metab Lab, B-1200Brussels, Belgium Univ Catholique Louvain Brussels Belgium B-1200 B-1200Brussels, Belgium
Titolo Testata:
ADVANCED DRUG DELIVERY REVIEWS
fascicolo: 2-3, volume: 45, anno: 2000,
pagine: 217 - 228
SICI:
0169-409X(200012)45:2-3<217:BMIPAD>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VIVO MICRODIALYSIS; PLASMA-PROTEIN BINDING; FREELY-MOVING RATS; TRANSPORTER STUDIED INVIVO; TANDEM MASS-SPECTROMETRY; INTRAVENOUS MICRODIALYSIS; BRAIN-BARRIER; LIQUID-CHROMATOGRAPHY; COLCHICINE SECRETION; PROBE;
Keywords:
microdialysis probes; surgical implantation; plasma protein binding; blood-brain barrier; biliary excretion; clinical applications;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Verbeeck, RK Univ Catholique Louvain, Sch Pharm, Pharmacokinet & Drug Metab Lab, PMNT 7369,Av E Mounier 73, B-1200 Brussels, Belgium Univ Catholique Louvain PMNT 7369,Av E Mounier 73 Brussels Belgium B-1200
Citazione:
R.K. Verbeeck, "Blood microdialysis in pharmacokinetic and drug metabolism studies", ADV DRUG DE, 45(2-3), 2000, pp. 217-228

Abstract

Microdialysis is a sampling technique allowing measurement of endogenous and exogenous substances in the extracellular fluid surrounding the probe. In vivo microdialysis sampling offers several advantages over conventional methods of studying the pharmacokinetics and metabolism of xenobiotics, bothin experimental animals and humans. In the first part of this review article various practical aspects related to blood microdialysis will be discussed, such as: probe design, surgical implantation techniques, methods to determine the in vivo relative recovery of the analyte of interest by the probe, special analytical considerations related to small volume microdialysatesamples, and pharmacokinetic calculations based on microdialysis data. In the second part of this review a few selected applications of in vivo microdialysis sampling to investigate pharmacokinetic processes are briefly discussed: determination of in vivo plasma protein binding in small laboratory animals, distribution of drugs across the blood-brain barrier, the use of microdialysis sampling to study biliary excretion and enterohepatic cycling,blood microdialysis sampling in man and in the mouse, and in vivo drug metabolism studies. (C) 2000 Elsevier Science BN. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 09:42:21