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Titolo:
Expression of beta-catenins and cadherins by follicular dendritic cells inhuman lymph nodes
Autore:
Muller, J; Tvrdik, D; Dvorak, R; Djaborkhel, R; Mandys, V; Bednar, B; Raska, I; Lojda, Z;
Indirizzi:
Acad Sci Czech Republ, Inst Expt Med, Dept Cell Biol, CZ-12800 Prague 2, Czech Republic Acad Sci Czech Republ Prague Czech Republic 2 0 Prague 2, Czech Republic Charles Univ, Fac Med 3, Gene Express Lab, CR-11636 Prague, Czech RepublicCharles Univ Prague Czech Republic CR-11636 11636 Prague, Czech Republic Acad Sci Czech Republ, Inst Expt Med, Dept Cell Pathol, Prague, Czech Republic Acad Sci Czech Republ Prague Czech Republic hol, Prague, Czech Republic Charles Univ, Hlava Inst Pathol, Fac Med 1, CR-11636 Prague 1, Czech Republic Charles Univ Prague Czech Republic 1 , CR-11636 Prague 1, Czech Republic Charles Univ, Fac Med 1, Inst Histol & Embryol, Lab Histochem, Prague 2, Czech Republic Charles Univ Prague Czech Republic 2 Histochem, Prague 2, Czech Republic
Titolo Testata:
ACTA HISTOCHEMICA
fascicolo: 4, volume: 102, anno: 2000,
pagine: 369 - 380
SICI:
0065-1281(200011)102:4<369:EOBACB>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADHESION MOLECULES; ENDOTHELIAL-CELL; EPITHELIAL-CELLS; GERMINAL CENTER; GAP-JUNCTIONS; PROLIFERATION; ANTIBODIES; IDENTIFICATION; LYMPHOCYTES; CONNEXIN43;
Keywords:
follicular dendritic cells; adherens junctions; cadherins; ss-catenin; human; lymphatic follicle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Muller, J Acad Sci Czech Republ, Inst Expt Med, Dept Cell Biol, Albertov 4, CZ-12800Prague 2, Czech Republic Acad Sci Czech Republ Albertov 4 PragueCzech Republic 2 public
Citazione:
J. Muller et al., "Expression of beta-catenins and cadherins by follicular dendritic cells inhuman lymph nodes", ACT HISTOCH, 102(4), 2000, pp. 369-380

Abstract

In lymph nodes, dendritic cells form a complex meshwork and are linked by intercellular junctions. Intercellular junctions contribute to the integrity of lymphatic follicles and can potentially be affected by malignant processes in neighbouring B cells. We examined whether transmembrane molecules that constitute "adherens junctions" are present in follicular dendritic cells of normal human lymph nodes. We found that follicular dendritic cells but not interdigitating dendritic cells or sinus lining cells expressed cadherin molecules. Follicular dendritic cells also expressed beta -catenin but not vinculin. The cadherin molecules, which were identified in situ with the use of a monoclonal pan-cadherin antibody, were not recognized by antibodies to E-cadherin, N-cadherin or beta -cadherin. Intrafollicularly, cadherins were clearly colocalized with beta -catenins, in a dot-like fashion. We also detected intrafollicular expression of desmogleins and desmosomal plaque proteins. These findings indicate the presence of desmosomes within the dendritic meshwork. However, pan-cadherin reactivity was not only colocalized with desmoglein immunoreactivity that was abundantly present. Immunoprecipitation showed that pan-cadherin reactivity was absent in fractions of desmosomal plaque proteins or pan-desmogleins. We speculate that complexes ofcadherins of an unknown subclass and beta -catenins form non-desmosomal intercellular junctions in the intrafollicular dendritic meshwork.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 05:12:31