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Titolo:
Efficacies of BCG and vole bacillus (Mycobacterium microti) vaccines in preventing clinically apparent pulmonary tuberculosis in rabbits: a preliminary report
Autore:
Dannenberg, AM; Bishai, WR; Parrish, N; Ruiz, R; Johnson, W; Zook, BC; Boles, JW; Pitt, LM;
Indirizzi:
Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Environm Hlth Sci, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 th Sci, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 mmunol, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Int Hlth Epidemiol, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 demiol, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Pathol Med, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 ol Med, Baltimore, MD 21205 USA George Washington Univ, Med Ctr, Dept Pathol, Washington, DC 20037 USA George Washington Univ Washington DC USA 20037 , Washington, DC 20037 USA George Washington Univ, Med Ctr, Dept Anim Res, Washington, DC 20037 USA George Washington Univ Washington DC USA 20037 , Washington, DC 20037 USA USA, Med Res Inst Infect Dis, Dept Aerobiol & Prod Evaluat, Ft Detrick, MD21702 USA USA Ft Detrick MD USA 21702 obiol & Prod Evaluat, Ft Detrick, MD21702 USA
Titolo Testata:
VACCINE
fascicolo: 7-8, volume: 19, anno: 2000,
pagine: 796 - 800
SICI:
0264-410X(20001122)19:7-8<796:EOBAVB>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIRULENCE; STRAINS;
Keywords:
tuberculosis; BCG and vole bacillus vaccines; tubercle-count method;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Dannenberg, AM Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Environm HlthSci, 615 N Wolfe St, Baltimore, MD 21205 USA Johns Hopkins Univ 615 N Wolfe St Baltimore MD USA 21205 SA
Citazione:
A.M. Dannenberg et al., "Efficacies of BCG and vole bacillus (Mycobacterium microti) vaccines in preventing clinically apparent pulmonary tuberculosis in rabbits: a preliminary report", VACCINE, 19(7-8), 2000, pp. 796-800

Abstract

Tuberculosis (TB) kills more people in the world today than any other infectious disease, and the number of drug-resistant Mycobacterium tuberculosisisolates is increasing. Vaccines, better than most of the currently available strains of bacille Calmette-Guerin (BCG), are urgently needed to control this disease. TB in rabbits resembles human TB more closely than TB in any other common laboratory animal and a most pertinent method of assessing vaccine efficacy is Lurie's tubercle count method in this species. Vaccinated and control rabbits were infected by aerosol with virulent human-type tubercle bacilli (H37Rv). At necropsy 5 weeks thereafter, the grossly visible primary tubercles in the entire lung were counted. A decrease in the numberof such tubercles is a quantitative measure of vaccine efficacy: An effective vaccine prevents microscopic tubercles from growing to grossly visible (clinically apparent) size. The Pasteur substrain of BCG and two substrainsof Mycobacterium microti (the vole bacillus) reduced the number of visibleprimary tubercles an average of 75%, whereas three other substrains of BCGand three other substrains of vole bacilli only reduced the number an average of 40%. These initial studies indicate that Lurie's tubercle-count method in rabbits is a precise way to choose the best available tuberculosis vaccines. (C) 2000 Elsevier Science Ltd. All rights reserved.

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Documento generato il 21/09/20 alle ore 18:40:43