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Titolo:
Molecular basis of clarithromycin-resistance in Mycobacterium avium intracellulare complex
Autore:
Jamal, MA; Maeda, S; Nakata, N; Kai, M; Fukuchi, K; Kashiwabara, Y;
Indirizzi:
Natl Inst Infect Dis, Leprosy Res Ctr, Dept Microbiol, Higashimurayama, Tokyo 1890002, Japan Natl Inst Infect Dis Higashimurayama Tokyo Japan 1890002 o 1890002, Japan Showa Univ, Dept Clin Pathol, Tokyo, Japan Showa Univ Tokyo JapanShowa Univ, Dept Clin Pathol, Tokyo, Japan
Titolo Testata:
TUBERCLE AND LUNG DISEASE
fascicolo: 1, volume: 80, anno: 2000,
pagine: 1 - 4
SICI:
0962-8479(2000)80:1<1:MBOCIM>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
23S RIBOSOMAL-RNA; HELICOBACTER-PYLORI; ERYTHROMYCIN RESISTANCE; MACROLIDE RESISTANCE; ESCHERICHIA-COLI; DRUG-RESISTANCE; GENETIC-BASIS; MUTATIONS; ETHAMBUTOL; BACTEREMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Kashiwabara, Y Natl Inst Infect Dis, Leprosy Res Ctr, Dept Microbiol, 4-2-1 Aoba Cho, Higashimurayama, Tokyo 1890002, Japan Natl Inst Infect Dis 4-2-1 Aoba Cho Higashimurayama Tokyo Japan 1890002
Citazione:
M.A. Jamal et al., "Molecular basis of clarithromycin-resistance in Mycobacterium avium intracellulare complex", TUBERC LUNG, 80(1), 2000, pp. 1-4

Abstract

Nucleotide sequences of domain V and domain II regions of the 23S rRNA gene were determined in both in vitro-made mutants and clinical isolates of Mycobacterium avium and M. intracellulare conferring clarithromycin-resistance. All laboratory-made mutants showed high level resistance to clarithromycin (>150 mug ml(-1)) and mutation at position 2058 (cognate with Escherichia coli base) in domain V region. In the clinical isolates, while the susceptible ones had no mutation in domain V, the resistant strains showed mutation at 2058 or 2059. Six isolates with low level of resistance exhibited no mutation in domain V. AII strains tested had no mutation in domain II region. These results suggested that most of the resistance arose from the mutation in domain V of the 23S rRNA gene, but other unknown mechanisms evidently exist in mycobacteria. (C) 2000 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 19:59:48