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Titolo:
Neurochemistry and neuropharmacology of emesis - the role of serotonin
Autore:
Endo, T; Minami, M; Hirafuji, M; Ogawa, T; Akita, K; Nemoto, M; Saito, H; Yoshioka, M; Parvez, SH;
Indirizzi:
Hlth Sci Univ Hokkaido, Fac Pharmaceut Sci, Dept Pharmacol, Ishikari, Hokkaido 0610293, Japan Hlth Sci Univ Hokkaido Ishikari Hokkaido Japan 0610293ido 0610293, Japan Japanese Red Cross Hokkaido Coll Nursing, Dept Basic Sci, Kitami, Hokkaido0900011, Japan Japanese Red Cross Hokkaido Coll Nursing Kitami Hokkaido Japan 0900011 an Hokkaido Univ, Sch Med, Dept Pharmacol, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 oro, Hokkaido 0608638, Japan Univ Reims, F-51687 Reims 2, France Univ Reims Reims France 2Univ Reims, F-51687 Reims 2, France
Titolo Testata:
TOXICOLOGY
fascicolo: 1-3, volume: 153, anno: 2000,
pagine: 189 - 201
SICI:
0300-483X(20001116)153:1-3<189:NANOE->2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
NK1 RECEPTOR ANTAGONIST; ABDOMINAL VISCERAL INNERVATION; CISPLATIN-INDUCED EMESIS; PERFUSED SMALL-INTESTINE; DORSAL VAGAL COMPLEX; GUINEA-PIG ILEUM; AREA POSTREMA; 5-HYDROXYTRYPTAMINE RELEASE; 5-HT4 RECEPTORS; COPPER-SULFATE;
Keywords:
emesis; 5-HT; 5-HT3 receptor; 5-HT4 receptor; 5-HT release; vagal afferent nerve;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
90
Recensione:
Indirizzi per estratti:
Indirizzo: Endo, T Hlth Sci Univ Hokkaido, Fac Pharmaceut Sci, Dept Pharmacol, 1757, Ishikari, Hokkaido 0610293, Japan Hlth Sci Univ Hokkaido 1757 Ishikari Hokkaido Japan 0610293 Japan
Citazione:
T. Endo et al., "Neurochemistry and neuropharmacology of emesis - the role of serotonin", TOXICOLOGY, 153(1-3), 2000, pp. 189-201

Abstract

Emesis is an instinctive defense reaction caused by the somato-autonomic nerve reflex which is integrated in the medulla oblongata. Emesis caused by cytotoxic drugs and radiation is associated with an increase in the concentration of 5-hydroxytryptamine (5-HT) in the intestinal mucosa and in the brainstem. 5-HT released from enterochromaffin (EC) cells, which synthesize and secrete 5-HT, stimulates the 5-HT, receptors on the adjacent vagal afferent nerves. This vagal afferent nerve depolarization may evoke the vomitingreflex. This review describes the role of 5-HT in anticancer drug-induced emesis from the viewpoint of 5-HT release from EC cells and afferent vagus nerve activity. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 15:12:07