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Titolo:
The role of frozen section, gender, age, and tumor size in the differentiation of follicular adenoma from carcinoma: A meta-analysis
Autore:
Miltenburg, DM; Prost, HM; Graviss, EA; Arem, R;
Indirizzi:
Baylor Coll Med, Michael E DeBaket Dept Surg, Houston, TX 77030 USA BaylorColl Med Houston TX USA 77030 ket Dept Surg, Houston, TX 77030 USA Baylor Coll Med, Dept Internal Med, Houston, TX 77030 USA Baylor Coll MedHouston TX USA 77030 Internal Med, Houston, TX 77030 USA Baylor Coll Med, Dept Pathol & Med, Houston, TX 77030 USA Baylor Coll MedHouston TX USA 77030 Pathol & Med, Houston, TX 77030 USA
Titolo Testata:
SURGERY
fascicolo: 6, volume: 128, anno: 2000,
pagine: 1075 - 1081
SICI:
0039-6060(200012)128:6<1075:TROFSG>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
FINE-NEEDLE ASPIRATION; HURTHLE CELL NEOPLASMS; THYROID-NODULES; OPERATIVE MANAGEMENT; DIAGNOSIS; LESIONS; MALIGNANCY; CYTOLOGY; UTILITY; BIOPSY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Miltenburg, DM Baylor Coll Med, Michael E DeBaket Dept Surg, 6550 Fannin,Suite 1625, Houston, TX 77030 USA Baylor Coll Med 6550 Fannin,Suite 1625 Houston TX USA 77030
Citazione:
D.M. Miltenburg et al., "The role of frozen section, gender, age, and tumor size in the differentiation of follicular adenoma from carcinoma: A meta-analysis", SURGERY, 128(6), 2000, pp. 1075-1081

Abstract

Background. The purpose of this study was to reanalyze modern trials and use meta-analysis to determine how well frozen section gender, age, and tumor size could differentiate follicular adenoma from follicular carcinoma. Method. Inclusion criteria were studies where patients had a permanent pathologic diagnosis of follicular adenoma or follicular carcinoma and underwent frozen section or had clinical features recorded. Data were pooled, and the random effects model of meta-analysis was used. A probability value of less than .05 was considered significant. Results. Nineteen studies were included (n = 3486 patients). Frozen section was evaluated in 11 studies (n = 2204 patients). Frozen section had an 87% sensitivity, a 48% specificity, a 92% and 35% positive and negative predictive value, respectively, an 82% accuracy, an odds ratio of 0.181, a 95% confidence interval (CI) of 0.07 to 0.49, and a probability value of .001. Clinical features were evaluated in 10 studies (n = 1954 patients). Of the patients with follicular carcinoma, 27.5% were male compared with patients with follicular adenoma, of whom 17.7% were male (P < .01; odds ratio, 2.17;CI 1.3-3.6; P = .003). Of the patients with follicular carcinoma, 52.2% were older than 50 years (52.2%) compared with patients with follicular adenoma, of whom 28.5% were older than 50 years (P < .001). Of patients with follicular carcinoma, 36.8% had tumors larger than 3 to 5 cm compared with patients with follicular adenoma, of whom 14.7% had tumors larger than 3 to 5 cm (P < .001; odds ratio, 3.99 CI 1.5-10.8; P = .006). Conclusions. Meta-analysis suggests that frozen section is not a specific test and cannot be used to confidently rule out follicular carcinoma. Male gender and large tumor size are significantly associated with carcinoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 07:14:07