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Titolo:
Overexpression of heme oxygenase-1 protects allogeneic thyroid grafts fromrejection in naive mice
Autore:
Niimi, M; Takashina, M; Takami, K; Ikeda, Y; Shatari, T; Hamano, K; Esato, K; Matsumoto, K; Kameyama, K; Kodaira, S; Wood, KJ;
Indirizzi:
Teikyo Univ, Dept Surg 1, Itabashi Ku, Tokyo 1738605, Japan Teikyo Univ Tokyo Japan 1738605 urg 1, Itabashi Ku, Tokyo 1738605, Japan Yamaguchi Univ, Dept Surg 1, Yamaguchi, Japan Yamaguchi Univ Yamaguchi Japan uchi Univ, Dept Surg 1, Yamaguchi, Japan Keio Univ, Dept Surg, Tokyo, Japan Keio Univ Tokyo JapanKeio Univ, Dept Surg, Tokyo, Japan Keio Univ, Div Diagnost Pathol, Tokyo, Japan Keio Univ Tokyo JapanKeio Univ, Div Diagnost Pathol, Tokyo, Japan Univ Oxford, Nuffield Dept Surg, Oxford, England Univ Oxford Oxford England Oxford, Nuffield Dept Surg, Oxford, England
Titolo Testata:
SURGERY
fascicolo: 6, volume: 128, anno: 2000,
pagine: 910 - 917
SICI:
0039-6060(200012)128:6<910:OOHOPA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL SUBSETS; ANTI-CD4 MONOCLONAL-ANTIBODY; ALLOGRAFT SURVIVAL; CARDIAC ALLOGRAFTS; OXIDANT STRESS; KAPPA-B; EXPRESSION; INHIBITION; ACTIVATION; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Niimi, M Teikyo Univ, Dept Surg 1, Itabashi Ku, 2-11-1 Kaga, Tokyo 1738605, Japan Teikyo Univ 2-11-1 Kaga Tokyo Japan 1738605 Tokyo 1738605, Japan
Citazione:
M. Niimi et al., "Overexpression of heme oxygenase-1 protects allogeneic thyroid grafts fromrejection in naive mice", SURGERY, 128(6), 2000, pp. 910-917

Abstract

Background. Endocrine allografts are an option for the treatment of endocrine failure. Methods. One lobe of the thyroid was transplanted tender the kidney capsule. Results, C57BL/10 (H2(b)) thyroids were rejected in naive CBA (H2(k) mice within 14 days after transplantation. When mice were treated with anti-CD4 monoclonal antibodies (mAb), all grafts survived for more than 60 days. Thefirst grafts still survived after second C57BL/10 or Balb/c (H2(d)) thyroid grafts that were transplanted into same recipients were rejected acutely,which suggests that the primary grafts were modified under anti-CD4 mAb treatment. To confirm this hypothesis, C57BL/10 thyroid grafts from anti-CD4 mAb-treated mice were retransplanted. All grafts survived in naive mice; this correlated with the overexpression of heme oxygenase-1 (HO-1) in the grafts Next, an inhibitor of HO-1 (zinc protoporphyrin) or control compound (copper protoporphyrin) was injected intraperitoneally after transplantation of C57BL/10 thyroid grafts into the primary CBA recipients that had been treated with anti-CD4 mAb. The grafts in mice that had been treated with zincprotoporphyrin, but not copper protoporphyrin, were rejected when retransplanted to naive recipients. Conclusions. Overexpression of HO-1 correlated, with the protection of fully allogeneic thyroid grafts from rejection when retransplanted into naive recipients.

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Documento generato il 01/12/20 alle ore 06:55:28