Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of dexamethasone on cytokine plasma levels and white blood cell counts in depressed patients
Autore:
Schuld, A; Kraus, T; Haack, M; Hinze-Selch, D; Zobel, AW; Holsboer, F; Pollmacher, T;
Indirizzi:
Max Planck Inst Psychiat, D-80804 Munich, Germany Max Planck Inst Psychiat Munich Germany D-80804 D-80804 Munich, Germany
Titolo Testata:
PSYCHONEUROENDOCRINOLOGY
fascicolo: 1, volume: 26, anno: 2001,
pagine: 65 - 76
SICI:
0306-4530(200101)26:1<65:EODOCP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; PITUITARY-ADRENAL AXIS; TNF RECEPTORS; GLUCOCORTICOIDS; ACTIVATION; METHYLPREDNISOLONE; INCREASE; THERAPY; RELEASE;
Keywords:
hypothalamus-pituitary-adrenal axis; glucocorticoids; interleukins; tumor necrosis factor-alpha; colony-stimulating factors; granulocytes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Schuld, A Max Planck Inst Psychiat, Kraepelinstr 10, D-80804 Munich, Germany Max Planck Inst Psychiat Kraepelinstr 10 Munich Germany D-80804
Citazione:
A. Schuld et al., "Effects of dexamethasone on cytokine plasma levels and white blood cell counts in depressed patients", PSYCHONEURO, 26(1), 2001, pp. 65-76

Abstract

In major depression, alterations of some aspects of the host defense system and the hypothalamo-pituitary-adrenal (HPA) system have been reported. Both systems are closely related, but their interaction in major depression has not yet been explored. Moreover, little is known about the effects of glucocorticoids on the circulating amounts of cytokines in humans in the absence of immunological challenges. Therefore, we investigated the effects of dexamethasone (DEX) in 17 depressed patients who underwent a combined DEX-suppression and corticotropine-releasing-hormone (CRH)-stimulation test on white blood cell counts, and on the plasma levels of granulocyte colony-stimulating factor (G-CSF), interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-alpha, and soluble TNF-receptors (sTNF-R) p55 and p75. DEX induced an increase in granulocyte counts, which was positively correlated with increases in the circulating amounts of G-CSF and paralleled by decreased lymphocyte and monocyte counts. Moreover, DEX reduced the plasma levels of IL-6, TNF-alpha and sTNF-R p75. The levels of sTNF-R p55 and IL-10 were not affected. DEX-induced changes in immunological parameters did not differ between patients who had different amounts of HPA-system alteration, and were neither related to the severity of depressive symptomatology or to other clinicalfeatures. We conclude that a single oral dose of DEX, even in the absence of infection and inflammation, affects the circulating amounts of cytokinesand soluble cytokine receptors, further supporting the pivotal role of these immune-mediators in glucocorticoid-induced immunomodulation. Neuroendocrinological alterations associated with major depression seem to be independent from these processes. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 14:53:19