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Titolo:
Volumetric asymmetries in late-onset mood disorders: an attenuation of frontal asymmetry with depression severity
Autore:
Kumar, A; Bilker, W; Lavretsky, H; Gottlieb, G;
Indirizzi:
Univ Calif Los Angeles, Sch Med, Inst Neuropsychiat, Los Angeles, CA 90024USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024USA Univ Penn, Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Epidemiol, Philadelphia, PA 19104 USA Harvard Univ, Massachusetts Gen Hosp, Sch Med, Mental Hlth Serv, Boston, MA 02114 USA Harvard Univ Boston MA USA 02114 , Mental Hlth Serv, Boston, MA 02114 USA
Titolo Testata:
PSYCHIATRY RESEARCH-NEUROIMAGING
fascicolo: 1, volume: 100, anno: 2000,
pagine: 41 - 47
SICI:
0925-4927(20001120)100:1<41:VAILMD>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL ASYMMETRY; PLANUM TEMPORALE; MAJOR DEPRESSION; BRAIN; SCHIZOPHRENIA; LOBES; MRI;
Keywords:
asymmetry; late-onset depression; geriatric depression; neuroanatomy; MRI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Kumar, A Univ Calif Los Angeles, Sch Med, Inst Neuropsychiat, 760 WestwoodPlaza,Rm37-384, Los Angeles, CA 90024 USA Univ Calif Los Angeles 760 Westwood Plaza,Rm 37-384 Los Angeles CA USA 90024
Citazione:
A. Kumar et al., "Volumetric asymmetries in late-onset mood disorders: an attenuation of frontal asymmetry with depression severity", PSYCH RES-N, 100(1), 2000, pp. 41-47

Abstract

The purpose of the study was to examine global and regional volumetric asymmetries in patients with late-onset mood disorders and non-depressed control subjects. Our sample comprised 34 patients with late-onset major depression, 18 patients diagnosed with late-onset minor depression and 30 control subjects. All subjects were scanned using a 1.5 Tesla GE Scanner, and quantitative estimates of global and focal brain volumes were obtained. Control subjects and patients displayed significant right-left Volumetric differences across several regions, with right-sided regions being larger than the left. In the frontal lobes, the asymmetry differed significantly in the three groups (P = 0.02). It was most pronounced in the control group and decreased significantly in the minor and major depression groups. There was a significant trend (P = 0.005) in the magnitude of frontal asymmetry across groups, with the frontal asymmetry decreasing with increasing severity of depression. Hemispheric and temporal asymmetries were comparable in all three groups. These data suggest that an attenuation of the 'normal' volumetric asymmetry in the frontal regions may provide a structural basis to late-onsetmood disorders (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 15:04:18