Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effect of venlafaxine on imipramine metabolism
Autore:
Albers, LJ; Reist, C; Vu, RL; Fujimoto, K; Ozdemir, V; Helmeste, D; Poland, R; Tang, SW;
Indirizzi:
Univ Calif Irvine, Coll Med, Dept Psychiat, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 Dept Psychiat, Irvine, CA 92697 USA VA Healthcare Syst, Dept Mental Hlth, Long Beach, CA 90822 USA VA Healthcare Syst Long Beach CA USA 90822 Hlth, Long Beach, CA 90822 USA Univ Toronto, Dept Pharmacol, Toronto, ON, Canada Univ Toronto Toronto ONCanada onto, Dept Pharmacol, Toronto, ON, Canada Univ Toronto, Dept Psychiat, Toronto, ON, Canada Univ Toronto Toronto ON Canada ronto, Dept Psychiat, Toronto, ON, Canada Ctr Addict & Mental Hlth, Neurogenet Sect, Toronto, ON, Canada Ctr Addict & Mental Hlth Toronto ON Canada net Sect, Toronto, ON, Canada Harbor UCLA Med Ctr, Dept Psychiat, Torrance, CA 90509 USA Harbor UCLA MedCtr Torrance CA USA 90509 sychiat, Torrance, CA 90509 USA
Titolo Testata:
PSYCHIATRY RESEARCH
fascicolo: 3, volume: 96, anno: 2000,
pagine: 235 - 243
SICI:
0165-1781(20001120)96:3<235:EOVOIM>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXIDATION POLYMORPHISM; DESIPRAMINE METABOLISM; HUMAN LIVER; IN-VITRO; PHARMACOKINETICS; FLUOXETINE; INHIBITORS; SPARTEINE; CYP2D6; DEXTROMETHORPHAN;
Keywords:
antidepressant; tricyclic; desipramine; human cytochrome P450; pharmacokinetics; drug-drug interactions;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Albers, LJ Vet Adm Med Ctr, Dept Psychiat 116A, 5901 E 7th St, Long Beach,CA 90822 USA Vet Adm Med Ctr 5901 E 7th St Long Beach CA USA 90822 90822 USA
Citazione:
L.J. Albers et al., "Effect of venlafaxine on imipramine metabolism", PSYCHIAT R, 96(3), 2000, pp. 235-243

Abstract

The present study was: designed to determine the effect of venlafaxine on imipramine metabolism in an attempt to elucidate the potential for cytochrome P450 drug-drug interactions with venlafaxine. We examined the metabolismof a single 100-mg dose of imipramine before and after treatment with venlafaxine, 50 mg three times a day. Eight male subjects were phenotyped for CYP2D6 activity. Two subjects were poor metabolizers of dextromethophan, anddata from the remaining six subjects (mean age = 45.3 +/- 15) were analyzed. Venlafaxine increased imipramine C-max and elevated AUC by 40%. Desipramine clearance and volume of distribution were reduced by 20% and 25%, respectively. These findings are consistent with a statistically significant, but clinically modest impact of venlafaxine on CYP2D6-metabolized substrates. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:06:18