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Titolo:
Expression of cyclooxygenase-2 and nitrotyrosine in human gastric mucose before and after Helicobacter pylori eradication
Autore:
Kimura, A; Tsuji, S; Tsujii, M; Sawaoka, H; Iijima, H; Kawai, N; Yasumaru, M; Kakiuchi, Y; Okuda, Y; Ali, Z; Nishimura, Y; Sasaki, Y; Kawano, S; Hori, M;
Indirizzi:
Osaka Univ, Grad Sch Med, Dept Internal Med & Therapeut, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 erapeut, Suita, Osaka 5650871, Japan Osaka Univ, Fac Med, Sch Allied Hlth Sci, Dept Clin Lab Sci, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 Lab Sci, Suita, Osaka 5650871, Japan
Titolo Testata:
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
fascicolo: 5, volume: 63, anno: 2000,
pagine: 315 - 322
SICI:
0952-3278(200011)63:5<315:EOCANI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; COLON-CANCER CELLS; INFECTION; CARCINOMA; DNA; APOPTOSIS; ISOFORMS; RISK; PEROXYNITRITE; GENOTOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Tsuji, S Osaka Univ, Grad Sch Med, Dept Internal Med & Therapeut, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 5650871, Japan
Citazione:
A. Kimura et al., "Expression of cyclooxygenase-2 and nitrotyrosine in human gastric mucose before and after Helicobacter pylori eradication", PROS LEUK E, 63(5), 2000, pp. 315-322

Abstract

To determine whether cure of Helicobacter pylori infection influences the expression of COX-2 and nitrotyrosine in the distal stomach of humans, biopsy specimens were examined immunohistochemically. H. pylori infection was determined using a rapid urease test, culture and histology. Positive staining of COX-2/nitrotyrosine in the epithelium was expressed as the percentageof stained cells to the total epithelial cells. There was a significant increase in COX-2/nitrotyrosine staining in H. pylori-positive subjects compared with H. pylori-negative subjects. Cure of the infection resulted in a sig nificant decrease in both COX-2/nitrotyrosinestaining in all patients (52.1 +/- 12.1 % vs 15.4 +/- 7.2 %, P < 0.001; and 57.3 +/- 13.6 % vs 36.1 +/- 18.0 %, P < 0.01, respectively). However, immunoreactivity of COX-2/nitrotyrosine was observed in all cases with intestinal metaplasia even after the cure of H. pylori infection. Thus, cure of H. pylori infection may decrease the risk of gastric carcinogenesis due to COX-2 and NO-related compounds in gastric mucosa but not in those patients with intestinal metaplasia. (C) 2000 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 23:28:23