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Titolo:
Opposite effects of myocardial stretch and verapamil on the complexity of the ventricular fibrillatory pattern: An experimental study
Autore:
Chorro, FJ; Canoves, J; Guerrero, J; Mainar, L; Sanchis, J; Soria, E; Such, LM; Rosado, A; Such, L; Lopez-Merino, V;
Indirizzi:
Hosp Clin Univ, Serv Cardiol, Valencia 46010, Spain Hosp Clin Univ Valencia Spain 46010 Serv Cardiol, Valencia 46010, Spain Univ Valencia, Dept Elect, E-46003 Valencia, Spain Univ Valencia Valencia Spain E-46003 Dept Elect, E-46003 Valencia, Spain Univ Valencia, Dept Physiol, E-46003 Valencia, Spain Univ Valencia Valencia Spain E-46003 pt Physiol, E-46003 Valencia, Spain
Titolo Testata:
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
fascicolo: 11, volume: 23, anno: 2000,
parte:, 1
pagine: 1594 - 1603
SICI:
0147-8389(200011)23:11<1594:OEOMSA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISOLATED RABBIT HEART; INDUCED ATRIAL-FIBRILLATION; ACTIVATED ION CHANNELS; MECHANOELECTRICAL FEEDBACK; ELECTRICAL RESTITUTION; CARDIAC FIBRILLATION; INDUCED ARRHYTHMIAS; DOMINANT FREQUENCY; CANINE HEARTS; DILATATION;
Keywords:
ventricular fibrillation; stretch; verapamil; mapping; electrophysiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Chorro, FJ Hosp Clin Univ, Serv Cardiol, Avda Blasco Ibanez 17, Valencia 46010, Spain Hosp Clin Univ Avda Blasco Ibanez 17 Valencia Spain 46010 pain
Citazione:
F.J. Chorro et al., "Opposite effects of myocardial stretch and verapamil on the complexity of the ventricular fibrillatory pattern: An experimental study", PACE, 23(11), 2000, pp. 1594-1603

Abstract

An experimental model is used to analyze the effects of ventricular stretching and verapamil on the activation patterns during VF. Ten Longendorff-perfused rabbit hearts were used to record VF activity with an epicardial multiple electrode before, during, and offer stretching with an intraventricular balloon, under both control conditions and during verapamil (Vp) infusion (0.4-0.8 mu mol). The analyzed parameters were dominant frequency (FrD) spectral analysis, the median (MN) of the VF intervals, and the type of activation maps during VF (I = one wavelet without block lines, II = two simultaneous wavelets with block lines, III = three or more wavelets with block lines). Stretch accelerates VF (FrD: 22.8 +/- 6.4 vs 25.2 +/- 1.0 Hz, P < 0.01; MN: 48 +/- 13 vs 68 +/- 6 ms, P < 0.02). On fitting the Fro time changes to an exponential model after applying and suppressing stretch, the time constants (stretch: 101.2 +/- 19.6 s; stretch suppression: 97.8 +/- 33.2 s)do not differ significantly. Stretching induces a significant variation inthe complexity of the VF activation maps with type III increments and typeI and II decrements (control: I = 17.5%, II = 50.5%, III = 32%; stretch: I= 7% II = 6.5%, III = 56.5%, P < 0.001). Vp accelerates VF (FrD: 20.9 +/- 1.9 Hz, P ( 0.001 vs control; MN: 50 +/- 5 ms, P < 0.002 vs control) and diminishes activation maps complexity (I = 25.5%, II = 60.5 %, III = 14%, P <0.002 vs control). On applying stretch during Vp perfusion, the fibrillatory process is not accelerated to any greater degree. However, type I and IImap decrements and type III increments are recorded, though reaching percentages similar to control (I = 16.5%, II = 53%, III = 30.5%, NS vs control). The following conclusions were found: (1) myocardial stretching accelerates VF and increases the complexity of the VF activation pattern; (2) time changes in the Fro of VF during and upon suppressing stretch fit an exponential model with similar time constants; and (3) although stretching and verapamil accelerate the VF process, they exert opposite effects upon the complexity of the fibrillatory pattern.

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Documento generato il 02/12/20 alle ore 15:27:56