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Titolo:
New descriptors of homogeneity of the propagation of ventricular repolarization
Autore:
Batchvarov, V; Dilaveris, P; Farbom, P; Ghuran, A; Acar, B; Hnatkova, K; Camm, AJ; Malik, M;
Indirizzi:
St George Hosp, Sch Med, Dept Cardiol Sci, London SW17 0RE, England St George Hosp London England SW17 0RE iol Sci, London SW17 0RE, England
Titolo Testata:
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
fascicolo: 11, volume: 23, anno: 2000,
parte:, 2
pagine: 1968 - 1972
SICI:
0147-8389(200011)23:11<1968:NDOHOT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
QT INTERVAL; DISPERSION; CARDIOMYOPATHY; HEART;
Keywords:
ventricular repolarization; autonomic modulation; ECG analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Batchvarov, V St George Hosp, Sch Med, Dept Cardiol Sci, Cranmer Terrace, London SW17 0RE, England St George Hosp Cranmer Terrace London England SW17 0RE land
Citazione:
V. Batchvarov et al., "New descriptors of homogeneity of the propagation of ventricular repolarization", PACE, 23(11), 2000, pp. 1968-1972

Abstract

Available descriptors of irregularities of ventricular repolarization are of limited clinical value. We studied the effect of autonomic variations onseveral new descriptors of the three-dimensional T loop. Twelve-lead digital ECGs were recorded continuously in 40 healthy subjects at baseline in the supine position, during postural changes (supine --> sitting --> standing--> supine --> standing), and during Valsalva maneuver performed three times in the supine and three times in the standing positions. A minimum dimensional space was constructed from the 12-lead EGG, using singular value decomposition, on the basis of median ECG beats constructed from 10-second consecutive ECG recordings. Temporal variations (TLA and FL, which measure theT loop area, and LD, the interlead relationship during repolarization) andwavefront direction descriptors (TCRT, the deviation between the QRS and Tvectors) were calculated and expressed as normalized values. Values of TLA, FL, and TCRT were significantly low er in the sitting than in the supine position (-38139 +/- 9099 vs 47133 +/- 7511, -0.017 +/- 0.005 vs 0.033 +/- 0.005 and -0.032 +/- 0.019 vs 0.071 +/- 0.015, respectively P < 0.001 for all) and decreased further in the standing position (-88288 +/- 14468, -0.067 +/- 0.013, -0.198 +/- 0.025, respectively P < 0.001 for all). LD increased from supine to sitting (98.7 +/- 29.4 vs -87.5 +/- 15.2, P < 0.001) and increased further, though nonsignificantly in the standing position (118.3 +/- 35.2). TLA, FL, and TCRT decreased from baseline during Valsalva in the supine (-34118 +/- 11424 vs 62234 +/- 12215, -0.038 +/- 0.014 vs 0.065 +/- 0.010, -0.08 +/- 0.03 vs 0.10 +/- 0.02, respectively, P < 0.002 for all) and standing positions (-108263 +/- 21051 vs -68909 +/- 10271, -0.109 +/- 0.014 vs -0.048 +/- 0.009, -0.30 +/- 0.035 vs -015 +/- 0.016, respectively, P < 0.05 for all). LD was significantly increased by Valsalva in the supine position (13 +/- 46 vs -153 +/- 30 P < 0.001) and nonsignificantly in the standing position (99 +/- 50 vs 86 +/- 30, P = NS). There were significant correlations among TLA, FL, and LD, and no significant correlation between TCRT and any of the temporal variation descriptors. These new temporal and wavefront direction descriptors are sensitive and rapid detectors of autonomic effects on ventricular repolarization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 02:33:22