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Titolo:
Effects of prenatal cocaine exposure on dopamine system development: a meta-analysis
Autore:
Glatt, SJ; Bolanos, CA; Trksak, GH; Jackson, D;
Indirizzi:
Northeastern Univ, Dept Psychol 125 NI, Boston, MA 02115 USA Northeastern Univ Boston MA USA 02115 sychol 125 NI, Boston, MA 02115 USA
Titolo Testata:
NEUROTOXICOLOGY AND TERATOLOGY
fascicolo: 5, volume: 22, anno: 2000,
pagine: 617 - 629
SICI:
0892-0362(200009/10)22:5<617:EOPCEO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-BRAIN; POSTNATAL-DEVELOPMENT; STRIATAL DOPAMINE; GESTATIONAL COCAINE; MATERNAL TOXICITY; RECEPTOR-BINDING; PREGNANCY; BEHAVIOR; FETAL; CONSEQUENCES;
Keywords:
prenatal cocaine; striatum; dopamine; D1 receptor; D2 receptor; meta-analysis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Jackson, D Northeastern Univ, Dept Psychol 125 NI, 360 Huntington Ave, Boston, MA 02115 USA Northeastern Univ 360 Huntington Ave Boston MA USA 02115 15 USA
Citazione:
S.J. Glatt et al., "Effects of prenatal cocaine exposure on dopamine system development: a meta-analysis", NEUROTOX T, 22(5), 2000, pp. 617-629

Abstract

Several studies have investigated the effects of prenatal cocaine (PCOC) exposure on the nigrostriatal dopaminergic system in animal models of maternal drug abuse, yet independent examinations of striatal dopamine (DA) receptors and tissue DA levels have produced equivocal results. The current meta-analysis provides a quantitative review of the literature on these topics,and analyzes potential moderators of the effects of PCOC exposure on thesevariables. The results indicate that the effects of PCOC exposure on striatal DA levels, D1 and D2 receptor-binding densities, and D2 receptor-binding affinity are negligible when collapsed over age, sex, species, and several other methodological variables. However, effects of PCOC exposure on somedopaminergic measures were significantly influenced by factors such as ageand sex. As expected, and as suggested by the selectivity and specificity of PCOC-induced changes reported in the published literature, the directionand magnitude of differences between genders or age groups in this study were not systematic across all dependent measures. Generally, PCOC exposure was more often linked to decreases, rather than increases, in the selected dependent measures. These findings indicate that PCOC exposure produces selective alterations in striatal dopaminergic system function which do not appear under all experimental circumstances, but which may be important factors in behavioral alterations seen in selected groups after PCOC exposure. (C) 2000 Elsevier Science Inc. Ail rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:55:41