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Titolo:
The expression of ion channel mRNAs in skeletal muscles from patients withmyotonic muscular dystrophy
Autore:
Kimura, T; Takahashi, MP; Okuda, Y; Kaido, M; Fujimura, H; Yanagihara, T; Sakoda, S;
Indirizzi:
Osaka Univ, Grad Sch Med, Dept Neurol D4, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 urol D4, Suita, Osaka 5650871, Japan Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 t Neurol, Boston, MA 02114 USA
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 3, volume: 295, anno: 2000,
pagine: 93 - 96
SICI:
0304-3940(200012)295:3<93:TEOICM>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED POTASSIUM CHANNELS; SMALL-CONDUCTANCE; RECEPTOR; GENE;
Keywords:
myotonic muscular dystrophy; voltage-gated ion channel; SK3; H1; amyotrophic lateral sclerosis; polymyositis; semiquantitative reverse transcriptase-polymerase chain reaction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Sakoda, S Osaka Univ, Grad Sch Med, Dept Neurol D4, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 650871, Japan
Citazione:
T. Kimura et al., "The expression of ion channel mRNAs in skeletal muscles from patients withmyotonic muscular dystrophy", NEUROSCI L, 295(3), 2000, pp. 93-96

Abstract

We investigated gene expression patterns of ion channels including the apamin-sensitive small-conductance Ca2+-activated K+ (SK3) channel, the adult isoform of the skeletal muscle Na+ channel (SkM1), the fetal isoform of skeletal muscle Na+ channel (H1), and the Cl- channel (CIC-1) by using the semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) for muscle samples from patients with adult onset myotonic dystrophy (DM), amyotrophic lateral sclerosis, and polymyositis. Patients with DM showed a significant increase in SK3 mRNA but not in mRNAs for other ion channels. The increased expression of SK3 gene in DM did not correlate with HI, the markerof muscle denervation, or the percentage of type 2C fiber, the marker of muscle regeneration. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 21:43:29