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Titolo:
Disparate spinal and supraspinal opioid antinociceptive responses in beta-endorphin-deficient mutant mice
Autore:
Mogil, JS; Grisel, JE; Hayward, MD; Bales, JR; Rubinstein, M; Belknap, JD; Low, MJ;
Indirizzi:
Oregon Hlth Sci Univ, Vollum Inst, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 m Inst, Portland, OR 97201 USA Oregon Hlth Sci Univ, VA Med Ctr, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 ed Ctr, Portland, OR 97201 USA Oregon Hlth Sci Univ, Dept Behav Neurosci, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 urosci, Portland, OR 97201 USA CONICET, Inst Invest Ingn Genet & Biol Mol, RA-1033 Buenos Aires, DF, Argentina CONICET Buenos Aires DF Argentina RA-1033 033 Buenos Aires, DF, Argentina Univ Illinois, Dept Psychol, Urbana, IL 61801 USA Univ Illinois Urbana ILUSA 61801 ois, Dept Psychol, Urbana, IL 61801 USA Univ Illinois, Neurosci Program, Urbana, IL 61801 USA Univ Illinois Urbana IL USA 61801 Neurosci Program, Urbana, IL 61801 USA Furman Univ, Dept Psychol, Greenville, SC 29613 USA Furman Univ Greenville SC USA 29613 ept Psychol, Greenville, SC 29613 USA
Titolo Testata:
NEUROSCIENCE
fascicolo: 3, volume: 101, anno: 2000,
pagine: 709 - 717
SICI:
0306-4522(2000)101:3<709:DSASOA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
MORPHINE-INDUCED ANALGESIA; STRESS-INDUCED ANALGESIA; RECEPTOR KNOCKOUT MICE; ORPHANIN-FQ; INTRACEREBROVENTRICULAR INJECTIONS; MULTIPLICATIVE INTERACTION; NOCICEPTIN/ORPHANIN FQ; PAIN; MECHANISMS; BRAIN;
Keywords:
analgesia; knockout; morphine; mu receptor; transgenic mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Low, MJ Oregon Hlth Sci Univ, Vollum Inst, L474, Portland, OR 97201 USA Oregon Hlth Sci Univ L474 Portland OR USA 97201 land, OR 97201 USA
Citazione:
J.S. Mogil et al., "Disparate spinal and supraspinal opioid antinociceptive responses in beta-endorphin-deficient mutant mice", NEUROSCIENC, 101(3), 2000, pp. 709-717

Abstract

The role of endogenous opioid systems in the analgesic response to exogenous opiates remains controversial. We previously reported that mice lacking the peptide neurotransmitter beta -endorphin, although unable to produce opioid-mediated stress-induced antinociception, nevertheless displayed intactantinociception after systemic administration of the exogenous opiate morphine. Morphine administered by a peripheral route can activate opioid receptors in both the spinal cord and brain. However, beta -endorphin neuronal projections are confined predominantly to supraspinal nociceptive nuclei. Therefore, we questioned whether the absence of beta -endorphin would differentially affect antinociceptive responses depending on the route of opiate administration. Time- and dose-response curves were obtained in beta -endorphin-deficient and matched wild-type C57BL/6 congenic control mice using thetail-immersion/withdrawal assay. Null mutant mice were found to be more sensitive to supraspinal (i.c.v.) injection of the mu -opioid receptor-selective agonists, morphine and D-Ala(2)-MePhe(4)-Gly-ol(5) enkephalin. In contrast, the mutant mice were less sensitive to spinal (i.t.) injection of these same drugs. Quantitative receptor autoradiography revealed no differencesbetween genotypes in the density of mu, delta, or kappa opioid receptor binding sites in either the spinal cord or pain-relevant supraspinal areas. Thus we report that the absence of a putative endogenous ligand for the mu -opioid receptor results in opposite changes in morphine sensitivity betweendiscrete areas of the nervous system, which are not simply caused by changes in opioid receptor expression. (C) 2000 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:29:24