Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Apolipoprotein E receptors: Linking brain development and Alzheimer's disease
Autore:
Herz, J; Beffert, U;
Indirizzi:
Univ Texas, SW Med Ctr, Dept Mol Genet, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 Ctr, Dept Mol Genet, Dallas, TX 75390 USA
Titolo Testata:
NATURE REVIEWS NEUROSCIENCE
fascicolo: 1, volume: 1, anno: 2000,
pagine: 51 - 58
SICI:
1471-0048(200010)1:1<51:AERLBD>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENSITY-LIPOPROTEIN RECEPTOR; AMYLOID PRECURSOR PROTEIN; PHOSPHOTYROSINE-BINDING DOMAIN; ALPHA-SECRETASE CLEAVAGE; BETA-PEPTIDE DEPOSITION; HUMAN FE65 GENE; NEURITE OUTGROWTH; ALPHA-2-MACROGLOBULIN RECEPTOR; MICE LACKING; CYTOPLASMIC DOMAIN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
100
Recensione:
Indirizzi per estratti:
Indirizzo: Herz, J Univ Texas, SW Med Ctr, Dept Mol Genet, 5323 Harry Hines Blvd, Dallas, TX 75390 USA Univ Texas 5323 Harry Hines Blvd Dallas TX USA 75390 TX 75390 USA
Citazione:
J. Herz e U. Beffert, "Apolipoprotein E receptors: Linking brain development and Alzheimer's disease", NAT REV NEU, 1(1), 2000, pp. 51-58

Abstract

Alzheimer's disease is a debilitating neurodegenerative disorder that afflicts an increasing part of our ageing population. An isoform of apolipoprotein E, a protein that mediates the transport of lipids and cholesterol in the circulatory system, predisposes carriers of this allele to the common late-onset form of the disease. How this protein is related to a neurodegenerative disorder is an enigma. Mounting evidence indicates that apolipoprotein E receptors, which are abundantly expressed in most neurons in the central nervous system, also fulfil critical functions during brain development and may profoundly influence the pathogenesis of Alzheimer's disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:27:05