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Titolo:
Use of population isolates for mapping complex traits
Autore:
Peltonen, L; Palotie, A; Lange, K;
Indirizzi:
Univ Helsinki, Dept Med Genet, FIN-00014 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00014 et, FIN-00014 Helsinki, Finland Natl Inst Publ Hlth, Helsinki, Finland Natl Inst Publ Hlth Helsinki Finland Inst Publ Hlth, Helsinki, Finland Univ Calif Los Angeles, Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Sch Med, Dept Biomath, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA
Titolo Testata:
NATURE REVIEWS GENETICS
fascicolo: 3, volume: 1, anno: 2000,
pagine: 182 - 190
SICI:
1471-0056(200012)1:3<182:UOPIFM>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENOME-WIDE SEARCH; FAMILIAL COMBINED HYPERLIPIDEMIA; MULTIPLE SUSCEPTIBILITY LOCI; LINKAGE DISEQUILIBRIUM; QUANTITATIVE TRAITS; DISEASE GENES; TRANSMISSION/DISEQUILIBRIUM TEST; VULNERABILITY LOCUS; RECESSIVE DEAFNESS; DIABETES-MELLITUS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
86
Recensione:
Indirizzi per estratti:
Indirizzo: Peltonen, L Univ Helsinki, Dept Med Genet, Haartmaninkatu 3, FIN-00014 Helsinki, Finland Univ Helsinki Haartmaninkatu 3 Helsinki Finland FIN-00014 and
Citazione:
L. Peltonen et al., "Use of population isolates for mapping complex traits", NAT REV GEN, 1(3), 2000, pp. 182-190

Abstract

Geneticists have repeatedly turned to population isolates for mapping and cloning Mendelian disease genes. Population' isolates possess many advantages in this regard. Foremost among these is the tendency for affected individuals to share ancestral haplotypes derived from a handful of founders. These haplotype signatures have guided scientists in the fine mapping of scores of rare disease genes. The past successes with Mendelian disorders using population isolates have prompted unprecedented interest among medical researchers in both the public and private sectors. Despite the obvious geneticand environmental complications, geneticists have targeted several population isolates for mapping genes for complex diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 00:05:41