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Titolo:
Analysis of hypophosphatemia in calcium nephrolithiasis
Autore:
Yamakawa, K; Kawamura, J;
Indirizzi:
Mie Univ, Sch Med, Dept Urol, Tsu, Mie 514, Japan Mie Univ Tsu Mie Japan 514 Univ, Sch Med, Dept Urol, Tsu, Mie 514, Japan
Titolo Testata:
MOLECULAR UROLOGY
fascicolo: 4, volume: 4, anno: 2000,
pagine: 365 - 370
SICI:
1091-5362(200024)4:4<365:AOHICN>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ABSORPTIVE HYPERCALCIURIA; IDIOPATHIC HYPERCALCIURIA; SERUM 1,25-DIHYDROXYVITAMIN-D; PRIMARY HYPERPARATHYROIDISM; PROXIMAL TUBULOPATHY; PHOSPHATE THERAPY; UROLITHIASIS; EXCRETION; RECEPTOR; ASSAY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Yamakawa, K Mie Univ, Sch Med, Dept Urol, 2-17 Edobashi, Tsu, Mie 514, Japan Mie Univ 2-17 Edobashi Tsu Mie Japan 514 , Tsu, Mie 514, Japan
Citazione:
K. Yamakawa e J. Kawamura, "Analysis of hypophosphatemia in calcium nephrolithiasis", MOL UROL, 4(4), 2000, pp. 365-370

Abstract

Purpose and Methods: To analyze the pathophysiology of hypophosphatemia incalcium nephrolithiasis, we investigated the relation between serum phosphorus, 1,25-dihydroxyvitamin D, and parathyroid hormone (PTH) levels in 63 consecutive patients with calcium nephrolithiasis, comparing them with 26 age-matched control subjects. Results: Serum phosphorus concentrations in normocalciuric and absorptive hypercalciuric stone formers were significantly decreased compared with control subjects (P < 0.001 and P < 0.01, respectively). The fractional excretion (TRP) and renal threshold (TmP/GFR) of phosphorus were significantly decreased in the subjects with nephrolithiasis (P < 0.01 and P < 0.001, respectively). Serum phosphorus concentrations were inversely correlated with serum 1,25-dihydroxyvitamin D in control subjects and in absorptive hypercalciuric stone formers (P < 0.01 and P < 0.05, respectively), suggesting that the physiologic relation between phosphorus and 1,25-dihydroxyvitamin D is maintained in these patients. Serum phosphorus concentrations in absorptivehypercalciuric patients, although related to 1,25-dihydroxyvitamin D, werenot related to PTH even though PTH and 1,25-dihydroxyvitamin D concentrations were directly related (P < 0.05). The lack of a relation between PTH and serum phosphorus concentrations in absorptive hypercalciuric stone formers was similar to that in controls. In normocalciuric stone formers, there was no relation between serum 1,25-dihydroxyvitamin D and serum phosphorus, but PTH and 1,25-dihydroxyvitamin D were inversely correlated (P < 0.05). Conclusions: Abnormal renal tubular function with a depressed rate of renal phosphorus transport and an abnormal 1,25-dihydroxyvitamin D concentration is common in nephrolithiasis, Differences in the relations between phosphorus and 1,25-dihydroxyvitamin D observed in hypercalciuric v normocalciuric subjects suggest that the pathogenesis of proximal tubulopathy differs among patients with nephrolithiasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 11:10:46