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Titolo:
Nonlinear dynamics in the progression of atherosclerotic fatty streaks: Morphometric analysis
Autore:
Bugelski, PJ; Maleeff, BE; Klinkner, AM; Louden, CS; Hart, TK;
Indirizzi:
SmithKline Beecham Pharmaceut, Safety Assessment US, Dept Safety Assessment, King Of Prussia, PA 19406 USA SmithKline Beecham Pharmaceut King Of Prussia PA USA 19406 , PA 19406 USA
Titolo Testata:
MICROSCOPY AND MICROANALYSIS
fascicolo: 6, volume: 6, anno: 2000,
pagine: 532 - 541
SICI:
1431-9276(200011/12)6:6<532:NDITPO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
OIL-RED-O; NILE RED; UNESTERIFIED CHOLESTEROL; FRACTAL DIMENSIONS; NEGATIVE PARTICLES; LIPID DEPOSITS; CHAOS; LESIONS; COMPLEXITY; PHYSIOLOGY;
Keywords:
filipin; Nile red; computer-assisted image processing; deterministic chaos; fractal dimension; succession; ecology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Maleeff, BE SmithKline Beecham Pharmaceut, Safety Assessment US, Dept Safety Assessment, UE0462,709 Swedeland Rd, King Of Prussia, PA 19406 USA SmithKline Beecham Pharmaceut UE0462,709 Swedeland Rd King Of Prussia PA USA 19406
Citazione:
P.J. Bugelski et al., "Nonlinear dynamics in the progression of atherosclerotic fatty streaks: Morphometric analysis", MICROS MICR, 6(6), 2000, pp. 532-541

Abstract

Atherosclerotic lesions are heterogeneous in terms of their cellular and lipid composition. While heterogeneity can be the result of stochastic noise, an alternate hypothesis is that the differences observed among individuallesions arise from deterministic chaos. Five New Zealand white rabbits were fed a diet containing 0.15% cholesterol for 6 months. Segments of the aorta were fixed in formalin, stained en bloc with Nile red (NR) and filipin (F), and en face fluorescence microscopy was used to map the distribution oflipids in fatty streaks (FS). The smallest lesions detected stained only with filipin. Larger lesions stained with both Nile red and filipin and two distinct regions of Nile red staining, NR-orange (rich in polar lipids) andNR-yellow (rich in neutral lipids) were observed. Digital overlays revealed a "nested" arrangement of F, NR-orange, and NR-yellow. The lesions also showed marked heterogeneity in their lipid composition. Thus, although initially similar, as FS increased in size, their composition became divergent, suggesting that the ultimate composition of a FS was highly sensitive to its initial composition. Sensitivity to initial condition is one of the hallmarks of deterministic systems. To determine if FS were self-similar, another hallmark of deterministic chaos, the borders of the different regions defined by NR and F staining were subjected to fractal analysis. For each lesion, the borders of the F, NR-orange, and NR-yellow regions were found to befractal. Return maps were constructed for the differently stained regions. Analysis of the entire 104-lesion data set showed that although the data could be described by a four-parameter logistic model, the population was not chaotic. However, return maps drawn for the maxima of the NR-orange stained regions demonstrated chaos. Taken together, the data suggest that deterministic chaos plays a role in the evolution of atheromatous disease but, incommon with most biologic systems, as the lesions progress, chaotic behavior is dampened.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:09:48