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Titolo:
Treatment of epilepsy in the multiply handicapped
Autore:
Pellock, JM; Morton, LD;
Indirizzi:
Virginia Commonwealth Univ Hlth Syst, MCV Hosp & Phys, Dept Neurol Pediat Pharm & Pharmaceut, Div Child Neurol, Richmond, VA USA Virginia Commonwealth Univ Hlth Syst Richmond VA USA l, Richmond, VA USA Virginia Commonwealth Univ Hlth Syst, MCV Hosp & Phys, Dept Neurol, Richmond, VA USA Virginia Commonwealth Univ Hlth Syst Richmond VA USA l, Richmond, VA USA
Titolo Testata:
MENTAL RETARDATION AND DEVELOPMENTAL DISABILITIES RESEARCH REVIEWS
fascicolo: 4, volume: 6, anno: 2000,
pagine: 309 - 323
SICI:
1080-4013(2000)6:4<309:TOEITM>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
REFRACTORY PARTIAL EPILEPSY; COMPLEX PARTIAL SEIZURES; LENNOX-GASTAUT-SYNDROME; RESISTANT PARTIAL SEIZURES; PLACEBO-CONTROLLED TRIAL; PARTIAL ONSET SEIZURES; SECONDARILY GENERALIZED SEIZURES; FAMILIAL NEONATAL CONVULSIONS; NEWLY-DIAGNOSED EPILEPSY; DOSE-RANGING TRIAL;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
196
Recensione:
Indirizzi per estratti:
Indirizzo: Pellock, JM Virginia Commonwealth Univ Hlth Syst, MCV Hosp & Phys, Div Neurol, Richmond, VA 23289 USA Virginia Commonwealth Univ Hlth Syst Richmond VA USA 23289 SA
Citazione:
J.M. Pellock e L.D. Morton, "Treatment of epilepsy in the multiply handicapped", MENT RET D, 6(4), 2000, pp. 309-323

Abstract

The medical management of epilepsy in the multi-handicapped patient requires careful evaluation, classification, and pharmacologic treatment. it is estimated that 20-40% of patients with mental retardation and cerebral palsyhave epilepsy. This review reports the clinical trial data and personal experience related to the use of newer AEDs in the chronic management of epilepsy syndromes in children and adults, as well as information available on the treatment of seizures in individuals with mental retardation and associated handicaps. Furthermore, clusters of seizures, prolonged seizures and status epilepticus are more commonly seen in the multiply handicapped and mentally retarded population and require special attention. The new antiepileptic drugs felbamate, gabapentin, lamotrigine, levetiracetam, oxcarbazepine, tiagabine, topiramate, vigabatrin and zonisamide show specific advantage in some multiply handicapped patients, be it for seizure control or medication tolerance. Furthermore, new modalities of treatment for prolonged seizures allow better efficacy both outside of hospital and within hospital facilities. The treatment of epilepsy in multihandicapped and retarded adults and children has significantly advanced in the past few years, and much of this improvement can be attributed to improved knowledge and monitoring of new antiepileptic drugs. Conventional anticonvulsants remain first line therapy for most clinicians, but newer AEDs must broaden the therapeutic optionand do allow improved therapy for some multiply handicapped patients. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:20:28