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Titolo:
Age dependent consequences of seizures: Relationship to seizure frequency,brain damage, and circuitry reorganization
Autore:
Lado, FA; Sankar, R; Lowenstein, D; Moshe, SL;
Indirizzi:
Albert Einstein Coll Med, Dept Neurol, Bronx, NY 10461 USA Albert EinsteinColl Med Bronx NY USA 10461 t Neurol, Bronx, NY 10461 USA Montefiore Med Ctr, Albert Einstein Coll Med, Epilepsy Management Ctr, Bronx, NY 10467 USA Montefiore Med Ctr Bronx NY USA 10467 Management Ctr, Bronx, NY 10467 USA Univ Calif Los Angeles, Sch Med, Dept Neurol, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Calif Los Angeles, Sch Med, Dept Pediat, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Calif Los Angeles, Mattel Childrens Hosp, Los Angeles, CA USA Univ Calif Los Angeles Los Angeles CA USA rens Hosp, Los Angeles, CA USA Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Epilepsy Res Lab, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10467 USA Albert Einstein Coll Med Bronx NY USA 10467 Neurosci, Bronx, NY 10467 USA Albert Einstein Coll Med, Dept Pediat, Bronx, NY 10467 USA Albert EinsteinColl Med Bronx NY USA 10467 t Pediat, Bronx, NY 10467 USA
Titolo Testata:
MENTAL RETARDATION AND DEVELOPMENTAL DISABILITIES RESEARCH REVIEWS
fascicolo: 4, volume: 6, anno: 2000,
pagine: 242 - 252
SICI:
1080-4013(2000)6:4<242:ADCOSR>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEMPORAL-LOBE EPILEPSY; INDUCED STATUS-EPILEPTICUS; SPONTANEOUS RECURRENT SEIZURES; NEURONAL MIGRATION DISORDERS; ACID-INDUCED SEIZURES; SUSTAINED ELECTRICAL-STIMULATION; INDUCED SYNAPTIC REORGANIZATION; HUMAN HIPPOCAMPAL EPILEPSY; LONG-TERM POTENTIATION; 1ST UNPROVOKED SEIZURE;
Keywords:
development; epilepsy; febrile seizure; hippocampus; status epilepticus;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
174
Recensione:
Indirizzi per estratti:
Indirizzo: Lado, FA Albert Einstein Coll Med, Dept Neurol, K313,1410 Pelham Pkwy S, Bronx, NY 10461 USA Albert Einstein Coll Med K313,1410 Pelham Pkwy S Bronx NY USA 10461
Citazione:
F.A. Lado et al., "Age dependent consequences of seizures: Relationship to seizure frequency,brain damage, and circuitry reorganization", MENT RET D, 6(4), 2000, pp. 242-252

Abstract

Seizures in the developing brain pose a challenge to the clinician. In addition to the acute effects of the seizure, there are questions regarding the impact of severe or recurrent seizures on the developing brain. Whether provoked seizures cause brain damage, synaptic reorganization, or epilepsy is of paramount importance to patients and physicians. Such questions are especially relevant in the decision to treat or not treat febrile seizures, acommon occurrence in childhood. These clinical questions have been addressed using clinical and animal research. The largest prospective studies do not find a causal connection between febrile seizures and later temporal robe epilepsy. The immature brain seems relatively resistant to the seizure-induced neuronal loss and new synapse formation seen in the mature brain. Laboratory investigations using a developmental rat model corresponding to human febrile seizures find that even though structural changes do not result from hyperthermic seizures, synaptic function may be chronically altered. The increased under standing of the cellular and synaptic mechanisms of seizure-induced damage may benefit patients and clinicians in the form of improved therapies to attenuate damage and changes induced by seizures and to prevent the development of epilepsy. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 21:43:04