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Titolo:
Vascular endothelial growth factor accelerates renal recovery in experimental thrombotic microangiopathy
Autore:
Kim, YG; Suga, S; Kang, DH; Jefferson, JA; Mazzali, M; Gordon, KL; Matsui, K; Breiteneder-Geleff, S; Shankland, SJ; Hughes, J; Kerjaschki, D; Schreiner, GF; Johnson, RJ;
Indirizzi:
Univ Washington, Med Ctr, Div Nephrol, Washington, DC USA Univ WashingtonWashington DC USA d Ctr, Div Nephrol, Washington, DC USA Sung Kyun Kwan Univ, Sch Med, Samsung Med Ctr, Div Nephrol, Seoul, South Korea Sung Kyun Kwan Univ Seoul South Korea , Div Nephrol, Seoul, South Korea SCIOS Inc, Sunnyvale, CA USA SCIOS Inc Sunnyvale CA USASCIOS Inc, Sunnyvale, CA USA Univ Vienna AKH, Dept Clin Pathol, Vienna, Austria Univ Vienna AKH Vienna Austria a AKH, Dept Clin Pathol, Vienna, Austria
Titolo Testata:
KIDNEY INTERNATIONAL
fascicolo: 6, volume: 58, anno: 2000,
pagine: 2390 - 2399
SICI:
0085-2538(200012)58:6<2390:VEGFAR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMOLYTIC-UREMIC-SYNDROME; INTRAMUSCULAR GENE-TRANSFER; THERAPEUTIC ANGIOGENESIS; CELLS; DISEASE; MECHANISMS; SURVIVAL; ISCHEMIA; ANTIBODY; HYPOXIA;
Keywords:
angiogenesis; ischemia; endothelium; hemolytic uremic syndrome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Johnson, RJ Baylor Coll Med, Renal Sect, 6650 Fannin,Suite 1273, Houston, TX 77030 USA Baylor Coll Med 6650 Fannin,Suite 1273 Houston TX USA 77030 SA
Citazione:
Y.G. Kim et al., "Vascular endothelial growth factor accelerates renal recovery in experimental thrombotic microangiopathy", KIDNEY INT, 58(6), 2000, pp. 2390-2399

Abstract

Background. Renal microvascular injury characterizes thrombotic microangiopathy (TMA). The possibility that angiogenic growth factors may accelerate recovery in TMA has not been studied. Methods. TMA was induced in rats by the selective right renal artery perfusion of antiglomerular endothelial cell IgG (30 mg/kg). Twenty-four hours later, rats received vascular endothelial growth factor (VEGF(121), 100 mug/kg/day) or vehicle (control) daily until day 14. To evaluate renal function, the unperfused left kidney was removed at day 14, and rats were sacrificed at day 17. Results. The induction of TMA was associated with loss of glomerular and peritubular capillary endothelial cells and decreased arteriolar density at day 1. Some spontaneous capillary recovery was present by day 17; however, repair was incomplete, and severe tubulointerstitial damage occurred. The lack of complete microvascular recovery was associated with reduced VEGF immunostaining in the outer medulla. VEGF-treated rats had more glomeruli withintact endothelium, less glomerular ischemia (collapsed glomeruli), and greater peritubular capillary density with less peritubular capillary loss. This was associated with less tubulointerstitial fibrosis, less cortical atrophy, and improved renal function. Conclusions. VEGF accelerates renal recovery in this experimental model ofTMA. These studies suggest that angiogenic growth factors may provide a new therapeutic strategy for diseases associated with endothelial cell injury.

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Documento generato il 27/11/20 alle ore 03:37:44