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Titolo:
Interneuronal survival and calbindin-D28K expression following motoneuron degeneration
Autore:
Lim, SMC; Guiloff, RJ; Navarrete, R;
Indirizzi:
Univ London Imperial Coll Sci Technol & Med, Dept Neuromuscular Dis, Div Neurosci & Psychol Med, London W6 8RF, England Univ London Imperial Coll SciTechnol & Med London England W6 8RF ngland
Titolo Testata:
JOURNAL OF THE NEUROLOGICAL SCIENCES
fascicolo: 1-2, volume: 180, anno: 2000,
pagine: 46 - 51
SICI:
0022-510X(20001101)180:1-2<46:ISACEF>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALCIUM-BINDING PROTEINS; RAT SPINAL-CORD; AMYOTROPHIC-LATERAL-SCLEROSIS; DISMUTASE TRANSGENIC MICE; DORSAL-ROOT GANGLIA; RENSHAW CELLS; VENTRAL HORN; D28K IMMUNOREACTIVITY; NERVOUS-SYSTEM; NEURONS;
Keywords:
axotomy; neurodegeneration; interneuron; motoneuron; Renshaw cell; spinal cord; calbindin-D28k; calcium binding proteins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Navarrete, R Univ London Imperial Coll Sci Technol & Med, Dept Neuromuscular Dis, Div Neurosci & Psychol Med, Fulham Palace Rd, London W6 8RF, England Univ London Imperial Coll Sci Technol & Med Fulham Palace Rd London England W6 8RF
Citazione:
S.M.C. Lim et al., "Interneuronal survival and calbindin-D28K expression following motoneuron degeneration", J NEUR SCI, 180(1-2), 2000, pp. 46-51

Abstract

Degeneration of both motoneurons and interneurons has been previously observed in amyotrophic lateral sclerosis, It is unclear whether interneuronal loss is due to an intrinsic neuronal defect or if it occurs secondary to loss of their target motoneurons. We have examined the target dependence of interneurons, their survival and alterations in the expression of the calcium binding protein, calbindin-D28k (CB), in the ventral horn of the rat lumbar cord after extensive motoneuron degeneration was induced by unilateral rhizotomy of spinal nerves L2-L6 at postnatal day 3 (P3). Counts of Nissl-stained cells at pll revealed no significant interneuronal death despite lossof 80% of their target motoneurons. At P6, some motoneurons transiently expressed CB on the operated side compared to the control side. Since most ofthese cells an destined to die, this transiently increased CB expression may represent an abortive attempt by the axotomised motoneurons to buffer the neurotoxic consequences of high intracellular calcium. In contrast, therewas a time-dependent decrease in CB expression in ventral horn interneurons, with only 35% of putative Renshaw cells expressing CB by P21. These results indicate that neonatal interneurons are capable of surviving the loss of their motoneuron targets, but alter their phenotype as indicated by functional alterations in calcium-binding proteins. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:32:43