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Titolo:
Cognitive change in motor neurone disease/amyotrophic lateral sclerosis (MND/ALS)
Autore:
Neary, D; Snowden, JS; Mann, DMA;
Indirizzi:
Univ Manchester, Manchester Royal Infirm, Dept Neurol, Manchester, Lancs, England Univ Manchester Manchester Lancs England rol, Manchester, Lancs, England Univ Manchester, Dept Med, Lab Med Acad Grp, Manchester, Lancs, England Univ Manchester Manchester Lancs England Grp, Manchester, Lancs, England
Titolo Testata:
JOURNAL OF THE NEUROLOGICAL SCIENCES
fascicolo: 1-2, volume: 180, anno: 2000,
pagine: 15 - 20
SICI:
0022-510X(20001101)180:1-2<15:CCIMND>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; FRONTOTEMPORAL DEMENTIA; PRESENILE-DEMENTIA; DEGENERATIVE DEMENTIA; RECOGNITION MEMORY; DISEASE; IMPAIRMENT; DYSFUNCTION; ASSOCIATION; ATTENTION;
Keywords:
motor neurone disease; amyotrophic lateral sclerosis; dementia; frontotemporal dementia; cognition; executive function;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Neary, D Univ Manchester, Manchester Royal Infirm, Dept Neurol, Manchester, Lancs, England Univ Manchester Manchester Lancs England hester, Lancs, England
Citazione:
D. Neary et al., "Cognitive change in motor neurone disease/amyotrophic lateral sclerosis (MND/ALS)", J NEUR SCI, 180(1-2), 2000, pp. 15-20

Abstract

A motor neuronopathy complicating frontotemporal dementia (FTD) has been recognised and designated FTD/motor neurone disease (MND). FTD is characterised by profound character change and altered social conduct, and executive deficits, reflecting focal degeneration of the frontal and temporal neocortex. The motor neuronopathy comprises bulbar palsy and limb amyotrophy. The major histological change is typically of microvaculation of the cerebral cortex, with atrophy of the bulbar neurones and anterior horn cells of the spinal cord. Ubiquitinated inclusion bodies occur in large pyramidal cortical neurones and in surviving cranial nerve nuclei and anterior horn cells. Evidence is emerging that same patients with classical MND/amyotrophic lateral sclerosis (ALS), who are thought not to be demented, develop cognitive deficits in the realm of frontal executive functions. Moreover, frontal lobeabnormalities have been demonstrated by neuroimaging. The findings point to a link between FTD/MND and cMND/ALS and suggest that a proportion of patients with cMND/ALS go on to develop FTD. Patients with cMND/ALS may not be equally vulnerable. The hypothesis is that patients who present with bulbarpalsy and amyotrophy, rather than corticospinal and corticobulbar features, may be most susceptible to the development of FTD. (C) 2000 Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 03:34:04