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Titolo:
Evaluation of gamma thalamotomy for parkinsonian and other tremors: survival of neurons adjacent to the thalamic lesion after gamma thalamotomy
Autore:
Ohye, C; Shibazaki, T; Ishihara, J; Zhang, J;
Indirizzi:
Hidaka Hosp, Funct & Gamma Knife Surg Ctr, Takasaki, Gumma, Japan Hidaka Hosp Takasaki Gumma Japan Knife Surg Ctr, Takasaki, Gumma, Japan
Titolo Testata:
JOURNAL OF NEUROSURGERY
, volume: 93, anno: 2000, supplemento:, 3
pagine: 120 - 127
SICI:
0022-3085(200012)93:<120:EOGTFP>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
KNIFE RADIOSURGERY; MOVEMENT-DISORDERS; PALLIDOTOMY; BRAIN;
Keywords:
gamma knife; thalamus; Parkinson's disease; tremor; ventralis intermedius nucleus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Ohye, C Hidaka Hosp, Funct & Gamma Knife Surg Ctr, 886 Nakaomachi, Takasaki, Gumma, Japan Hidaka Hosp 886 Nakaomachi Takasaki Gumma Japan aki, Gumma, Japan
Citazione:
C. Ohye et al., "Evaluation of gamma thalamotomy for parkinsonian and other tremors: survival of neurons adjacent to the thalamic lesion after gamma thalamotomy", J NEUROSURG, 93, 2000, pp. 120-127

Abstract

Object. The effects of gamma thalamotomy for parkinsonian and other kinds of tremor were evaluated. Methods. Thirty-six thalamotomies were performed in 31 patients by using a4-mm collimator. The maximum dose was 150 Gy in the initial six cases, which was reduced to 130 Gy thereafter. The longest follow-up period was 6 years. The target was determined on T-2-weighted and proton magnetic resonance(MR) images. The point chosen was in the lateral-most part of the thalamicventralis intermedius nucleus. This is in keeping with open thalamotomy aspracticed at the authors' institution. In 15 cases, gamma thalamotomy was the first surgical procedure. In other cases, previous therapeutic or vascular lesions were visible to facilitate targeting. Two types of tissue reaction were observed on MR imaging: a simple oval shape and a complex irregular shape. Neither of these changes affected the clinical course. In the majority of cases, the tremor subsided after a latentinterval of approximately 1 year after irradiation. The earliest response was demonstrated at 3 months. In five cases the tremor remained. In four ofthese cases, a second radiation session was administered. One of these four patients as well as another patient with an unsatisfactory result underwent open thalamotomy with microrecording. In both cases, depth recording adjacent to the necrotic area revealed normal neuronal activity, including therhythmic discharge of tremor. Minor coagulation was per formed and resulted in immediate and complete arrest of the remaining tremor. Conclusions. Gamma thalamotomy for Parkinson's disease seems to be an alternative useful method in selected cases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 07:33:21