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Titolo:
Secondary ion-molecule reactions in matrix-assisted laser desorption/ionization
Autore:
Knochenmuss, R; Stortelder, A; Breuker, K; Zenobi, R;
Indirizzi:
Swiss Fed Inst Technol, Organ Chem Lab, CH-8092 Zurich, Switzerland Swiss Fed Inst Technol Zurich Switzerland CH-8092 92 Zurich, Switzerland Cornell Univ, Dept Chem & Biol Chem, Ithaca, NY 14853 USA Cornell Univ Ithaca NY USA 14853 t Chem & Biol Chem, Ithaca, NY 14853 USA
Titolo Testata:
JOURNAL OF MASS SPECTROMETRY
fascicolo: 11, volume: 35, anno: 2000,
pagine: 1237 - 1245
SICI:
1076-5174(200011)35:11<1237:SIRIML>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLY-CHARGED IONS; GAS-PHASE BASICITIES; IONIZATION MASS-SPECTROMETRY; PROTON-TRANSFER REACTIONS; DESORPTION IONIZATION; PEPTIDE IONS; CATIONIZATION; REACTIVITY; ATTACHMENT; MECHANISMS;
Keywords:
matrix-assisted laser desorption/ionization; proton transfer; electron transfer; ion-molecule reactions;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Knochenmuss, R Swiss Fed Inst Technol, Organ Chem Lab, Univ Str 16, CH-8092 Zurich, Switzerland Swiss Fed Inst Technol Univ Str 16 Zurich Switzerland CH-8092
Citazione:
R. Knochenmuss et al., "Secondary ion-molecule reactions in matrix-assisted laser desorption/ionization", J MASS SPEC, 35(11), 2000, pp. 1237-1245

Abstract

Ion-molecule charge- and proton-transfer reactions in the desorption plumeare considered for the case of matrix-assisted laser desorption/ionization(MALDI) with ultraviolet laser excitation, and it is proposed that they are major determinants of the observed mass spectrum, Specific MALDI phenomena which are discussed include the dominance of singly charged ions and analyte-matrix or analyte-analyte signal suppression, Should any be formed, highly charged products can be reduced by reaction with neutral matrix, yet singly charged ions cannot generally be neutralized in the same manner, Ion suppression effects can also be explained by similar reactions, which in some cases involve interconversion of dissimilar ion types, The plume is proposed often to be more under thermodynamic rather than kinetic control owing to these secondary reactions, UV/MALDI mass spectra should therefore be largely predictable, given sufficient thermodynamic information, and appropriate experimental conditions of sufficient analyte and plume density. Copyright (C) 2000 John Wiley & Sons, Ltd.

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Documento generato il 25/09/20 alle ore 22:50:19