Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Infection by microsporidia disrupts the host cell cycle
Autore:
Scanlon, M; Shaw, AP; Zhou, CJ; Visvesvara, GS; Leitch, GJ;
Indirizzi:
Morehouse Sch Med, Dept Physiol, Atlanta, GA 30310 USA Morehouse Sch Med Atlanta GA USA 30310 ept Physiol, Atlanta, GA 30310 USA Morehouse Sch Med, Dept Anat, Atlanta, GA 30310 USA Morehouse Sch Med Atlanta GA USA 30310 , Dept Anat, Atlanta, GA 30310 USA Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA 30341 USA Ctr Dis Control & Prevent Atlanta GA USA 30341 Dis, Atlanta, GA 30341 USA
Titolo Testata:
JOURNAL OF EUKARYOTIC MICROBIOLOGY
fascicolo: 6, volume: 47, anno: 2000,
pagine: 525 - 531
SICI:
1066-5234(200011/12)47:6<525:IBMDTH>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VITRO CULTURE; TRICHINELLA-SPIRALIS; ENCEPHALITOZOON-CUNICULI; ENTEROCYTOZOON-BIENEUSI; AFRICAN TRYPANOSOMES; MUSCLE-CELLS; N-SP; AIDS; PATIENT; ARREST;
Keywords:
cyclins; Encephalitozoon; E. cuniculi; E. hellem; E. intestinalis; mitotic index; parasitophorous vacuole;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Scanlon, M Morehouse Sch Med, Dept Physiol, 720 Westview Dr Sw, Atlanta, GA 30310 USA Morehouse Sch Med 720 Westview Dr Sw Atlanta GA USA 30310 0 USA
Citazione:
M. Scanlon et al., "Infection by microsporidia disrupts the host cell cycle", J EUKAR MIC, 47(6), 2000, pp. 525-531

Abstract

Microsporidia of the genus Encephalitozoon infect mammalian cells and havebecome a source of morbidity and mortality in immunocompromised humans. Encephalitozoon microsporidia develop and mature within parasitophorous vacuoles, enlarging the vacuole over time until it eventually occupies most of the cytoplasm of the host cell. The ability of the host cell to accommodate such a large burden for several days suggests that the parasite subverts normal host cell processes to ensure optimal environmental conditions for itsgrowth and development. Since this environment would be threatened if celldivision of the host cell occurred, we have formulated the hypothesis thatinfection with Encephalitozoon microsporidia induces an arrest in the cellcycle of the host cell. In support of this hypothesis, we have found that mitotic index and DNA duplication are reduced in infected cells as comparedto uninfected cells. The number of host cell nuclei in S phase is increased. The levels of cyclin D1 and the percentage of cells in G1 are reduced; however, the levels of cyclin B1 are elevated even though the percentage of cells, in G2/M is decreased. These results suggest that host cells infectedwith Encephalitozoon microsporidia are blocked at multiple points in the cell cycle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 02:01:15