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Titolo:
Orally administered Panax notoginseng influence on rat spontaneous behaviour
Autore:
Cicero, AFG; Bandieri, E; Arletti, R;
Indirizzi:
Univ Modena, Dept Biomed Sci, Pharmacol Sect, I-41100 Modena, Italy Univ Modena Modena Italy I-41100 , Pharmacol Sect, I-41100 Modena, Italy
Titolo Testata:
JOURNAL OF ETHNOPHARMACOLOGY
fascicolo: 3, volume: 73, anno: 2000,
pagine: 387 - 391
SICI:
0378-8741(200012)73:3<387:OAPNIO>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
GINSENG TOTAL SAPONIN; DRUG DISCOVERY; MEDICINES;
Keywords:
Panax notoginseng; locomotor activity; emotivity; spontaneous behaviour; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Arletti, R Univ Modena, Dept Biomed Sci, Pharmacol Sect, Via Campi 287, I-41100 Modena, Italy Univ Modena Via Campi 287 Modena Italy I-41100 0 Modena, Italy
Citazione:
A.F.G. Cicero et al., "Orally administered Panax notoginseng influence on rat spontaneous behaviour", J ETHNOPHAR, 73(3), 2000, pp. 387-391

Abstract

Panax notoginseng root is highly prized in China for its supposed hemorheological properties. Its behavioural effects are still not scientifically investigated; therefore, our preliminary study aim is to evaluate the influence of this phyto-drug on rats spontaneous behaviour. High quality P. notoginseng root dry extract has been orally administered through gastric tube for 10 days in two doses (43 and 86 mg/kg in a volume of 5 ml/kg per day) andits effects on locomotion, emotional reactivity and nutrition have been evaluated in different groups of Wistar rats (ten per group) versus animals treated with 5 ml/kg per day of saline. Actimeter test, open field test and microstructural analysis of unconditioned behaviour were carried out. The data were processed by ANOVA-test followed by the Student's one-tail t-test and a 0.05 significance level was chosen for all statistical tests. A significant increase in spontaneous motility being not associated to an increasein grooming episodes duration and number was found in all tests (P<0.05). Feeding behaviour appeared not to be affected by the treatment. Observed effects did not seem dose-related. Reduction of grooming episodes duration and number and increase of inner crossings in open field suggested that notoginsenoides can modulate emotional responses in rats. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:24:51