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Titolo:
Effects of sex steroid deprivation/administration on hair growth and skin sebum production in transsexual males and females
Autore:
Giltay, EJ; Gooren, LJG;
Indirizzi:
Vrije Univ Amsterdam, Univ Hosp,Res Inst Endocrinol Reprod & Metab, Dept Endocrinol, Div Androl, NL-1007 MB Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands NL-1007 MB erdam, Netherlands
Titolo Testata:
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
fascicolo: 8, volume: 85, anno: 2000,
pagine: 2913 - 2921
SICI:
0021-972X(200008)85:8<2913:EOSSDO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
5-ALPHA-REDUCTASE ACTIVITY; IDIOPATHIC HIRSUTISM; 3-ALPHA-ANDROSTANEDIOL GLUCURONIDE; CYPROTERONE-ACETATE; ANDROGEN RECEPTORS; ACNE-VULGARIS; WOMEN; FOLLICLES; ESTROGEN; PLASMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Giltay, EJ Vrije Univ Amsterdam, Univ Hosp,Res Inst Endocrinol Reprod & Metab, Dept Endocrinol, Div Androl, POB 7057, NL-1007 MB Amsterdam, Netherlands Vrije Univ Amsterdam POB 7057 Amsterdam Netherlands NL-1007 MB
Citazione:
E.J. Giltay e L.J.G. Gooren, "Effects of sex steroid deprivation/administration on hair growth and skin sebum production in transsexual males and females", J CLIN END, 85(8), 2000, pp. 2913-2921

Abstract

To investigate androgen effects on the skin pilosebaceous unit, we studied21 male-to-female transsexuals and 17 female-to-male transsexuals receiving cross-sex hormones. At baseline and after 4, 8, and 12 months, hair growth was evaluated by the Ferriman-Gallwey score; acne by the Leeds classification; hair growth rate, density, and shaft diameter by image analysis; and sebum production by Sebutape. In males, estrogens and antiandrogens reducedplasma testosterone to below 1.0 nmoL/L. Though all parameters of hair growth and sebum production declined, facial hair growth continued. After 4 months, the decrease in shaft diameter had reached its maximum and seemed inversely associated with changes in hair growth length and density. In females, testosterone increased hair growth rate and sebum production. After 12 months, hairs on the cheek and abdomen had not yet reached diameters found in males. 5 alpha -Androstane-3 alpha ,17 beta -diol glucuronide levels wereonly weakly associated with hair growth and sebum production. In conclusion, administration of estrogens and antiandrogens affects length and diameter of hairs at different rates. In the virtual absence of androgens, hair growth continues but at a slower rate. In women, after 12 months of androgen administration, hair diameters have not reached values of adult men.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:35:27