Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Analysis of thyrotropin-releasing hormone-signaling components in pituitary adenomas of patients with acromegaly
Autore:
Ehrchen, J; Peters, A; Ludecke, DK; Visser, T; Bauer, K;
Indirizzi:
Max Planck Inst Expt Endokrinol, D-30625 Hannover, Germany Max Planck InstExpt Endokrinol Hannover Germany D-30625 nnover, Germany Univ Hamburg, Krankenhaus Eppendorf, Neurochirurg Klin, D-20246 Hamburg, Germany Univ Hamburg Hamburg Germany D-20246 rurg Klin, D-20246 Hamburg, Germany Erasmus Univ, Fac Med, Dept Internal Med & Clin Endocrinol 3, NL-3000 DR Rotterdam, Netherlands Erasmus Univ Rotterdam Netherlands NL-3000 DR DR Rotterdam, Netherlands
Titolo Testata:
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
fascicolo: 8, volume: 85, anno: 2000,
pagine: 2709 - 2713
SICI:
0021-972X(200008)85:8<2709:AOTHCI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RIBONUCLEIC-ACID; POLYMERASE CHAIN-REACTION; TRH-DEGRADING ECTOENZYME; ANTERIOR-PITUITARY; RECEPTOR GENE; RAT ANTERIOR; FUNCTIONAL EXPRESSION; MOLECULAR-CLONING; THYROID-HORMONES; NERVOUS-SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Bauer, K Max Planck Inst Expt Endokrinol, Feodor Lynen Str 7, D-30625 Hannover, Germany Max Planck Inst Expt Endokrinol Feodor Lynen Str 7 Hannover Germany D-30625
Citazione:
J. Ehrchen et al., "Analysis of thyrotropin-releasing hormone-signaling components in pituitary adenomas of patients with acromegaly", J CLIN END, 85(8), 2000, pp. 2709-2713

Abstract

In many acromegalic patients the paradoxical release of GH in response to TRH has been well documented, but the mechanisms underlying this phenomenonare not understood. It has been suggested that aberrant GH secretion may result from TRH endogenously synthesized by the adenoma. In 32 adenomas fromacromegalic patients, TRH-like immunoreactivity (TRH-LI) was measured using 2 well characterized antisera. TRH-LI was not detectable in 10 samples, and in 19 samples, TRH-LI was measured only by the less specific antibody. With the TRH-specific antibody, TRH-LI was identified only in 3 samples, 2 of which contained exceedingly high concentrations (40 and 96 pg/mg tissue). In the latter 2 samples, prepro-TRH messenger ribonucleic acid was identified by Northern blot analysis, but not in the control tissue sample of a patient without pituitary disease and also not in the other adenomas analyzedby this technique. Transcripts of the TRH receptor were almost undetectable in all adenomas analyzed. For the TRH-degrading ectoenzyme, a potential regulator of TRH signals at adenohypophyseal target sites, transcripts were significantly expressed only in the TRH-producing adenomas. We conclude that the TRH-signaling elements examined are, in general, not directly involved in the mechanisms causing paradoxical GH secretion in acromegalic patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 06:34:50