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Titolo:
Leukocytes infiltrating the submandibular glands of NOD mice express E-cadherin
Autore:
Esch, TR; Jonsson, MV; Levanos, VA; Poveromo, JD; Sorkin, BC;
Indirizzi:
Forsyth Inst, Harvard Forsyth Dept Oral Biol, Boston, MA 02115 USA ForsythInst Boston MA USA 02115 yth Dept Oral Biol, Boston, MA 02115 USA Forsyth Inst, Dept Immunol, Boston, MA USA Forsyth Inst Boston MA USAForsyth Inst, Dept Immunol, Boston, MA USA Univ Bergen, Fac Odontol, Bergen, Norway Univ Bergen Bergen NorwayUniv Bergen, Fac Odontol, Bergen, Norway Forsyth Inst, Dept Cytokine Biol, Boston, MA USA Forsyth Inst Boston MA USA syth Inst, Dept Cytokine Biol, Boston, MA USA
Titolo Testata:
JOURNAL OF AUTOIMMUNITY
fascicolo: 4, volume: 15, anno: 2000,
pagine: 387 - 393
SICI:
0896-8411(200012)15:4<387:LITSGO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPHOCYTE INTEGRIN ALPHA(E)BETA(7); NONOBESE DIABETIC MICE; MOLECULE E-CADHERIN; T-CELL DEVELOPMENT; LIGAND E-CADHERIN; SJOGRENS-SYNDROME; EPITHELIAL-CELLS; MURINE THYMOCYTES; EXOCRINE TISSUES; ADHESION;
Keywords:
adhesion molecules; autoimmunity; in vivo animal models; rodent;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Esch, TR Forsyth Inst, Harvard Forsyth Dept Oral Biol, 140 Fenway, Boston,MA 02115USA Forsyth Inst 140 Fenway Boston MA USA 02115 , Boston, MA 02115USA
Citazione:
T.R. Esch et al., "Leukocytes infiltrating the submandibular glands of NOD mice express E-cadherin", J AUTOIMMUN, 15(4), 2000, pp. 387-393

Abstract

Sjogren's syndrome [SS] is typified by infiltration of mononuclear cells [MNC] into the salivary and lacrimal glands, although the biological role ofthese infiltrating cells remains unclear. We report here that E-cadherin, which mediates cell-cell adhesion and regulates differentiation, proliferation, and apoptosis of epithelial cells, is expressed ectopically by MNC in the salivary glands in the NOD mouse model of SS. Flow cytometric analysis of CD45(+) cells from NOD submandibular glands revealed that over 90% express E-cadherin. More detailed phenotypic analyses demonstrated that E-cadherin expression is high (>90%) among mature T cells (CD3(+)), B cells (CD19(+)), NK cells (DX5(+)), and monocyte/macrophages (CD11b(+)) within the infiltrates. Expression of other surface antigens, such as CD90 and CD117, aboveexpected values suggests the presence of immature leukocytes, possibly of the T cell lineage, within the foci. We also present evidence that E-cadherin-expressing T cells in the glands do not exhibit normal proliferative responses to immobilized anti-CD3 antibody. While infiltrating MNC are not likely to be the direct cause of salivary hypofunction, the expression of E-cadherin by these cells may have implications for the progression of disease. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 01:15:36