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Titolo:
Pharmacological characterization of vasomotor activity of human musculocutaneous perforator artery and vein
Autore:
Zhang, JR; Lipa, JE; Black, CE; Huang, N; Neligan, PC; Ling, FTK; Levine, RH; Semple, JL; Pang, CY;
Indirizzi:
Hosp Sick Children, Res Inst, Toronto, ON M5G 1X8, Canada Hosp Sick Children Toronto ON Canada M5G 1X8 Toronto, ON M5G 1X8, Canada Univ Toronto, Dept Surg, Toronto, ON M5G 1X8, Canada Univ Toronto TorontoON Canada M5G 1X8 Surg, Toronto, ON M5G 1X8, Canada Univ Toronto, Dept Physiol, Toronto, ON M5G 1X8, Canada Univ Toronto Toronto ON Canada M5G 1X8 ysiol, Toronto, ON M5G 1X8, Canada
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 89, anno: 2000,
pagine: 2268 - 2275
SICI:
8750-7587(200012)89:6<2268:PCOVAO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-DEPENDENT RELAXATION; SKIN FLAP SURVIVAL; INTERNAL MAMMARY ARTERY; CALCIUM-ANTAGONISTS; CORONARY-ARTERY; ISCHEMIC NECROSIS; RELAXING FACTOR; PROTEIN-KINASE; SAPHENOUS-VEIN; NITROGLYCERIN;
Keywords:
tissue transplant; free flap; microvascular surgery; vasospasm; ischemic necrosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Pang, CY Hosp Sick Children, Res Inst, 555 Univ Ave, Toronto, ON M5G 1X8, Canada Hosp Sick Children 555 Univ Ave Toronto ON Canada M5G 1X8 Canada
Citazione:
J.R. Zhang et al., "Pharmacological characterization of vasomotor activity of human musculocutaneous perforator artery and vein", J APP PHYSL, 89(6), 2000, pp. 2268-2275

Abstract

Vasospasm is one of the main causes of skin ischemic necrosis in cutaneousand musculocutaneous flap surgery, but the pathogenic mechanism is unclear. We planned to test the hypothesis derived from clinical impression that veins are more susceptible to vasospasm than arteries in flap surgery and, once established, that venous vasospasm is difficult to resolve and more detrimental than arterial vasospasm. To this end, we investigated the differences in sensitivity to vasoconstrictors and vasodilators between the human musculocutaneous perforator (MCP) artery and vein by measuring the isometrictension of arterial and venous rings suspended in organ chambers. Vascularcontraction was expressed as a percentage of the tension induced by 50 mM KCl. Relaxation was expressed as a percentage of contraction induced by a submaximal concentration (3 x 10(-9) M) of endothelin-1 (ET-1). We observed that the vasoconstrictor potency of norepinephrine was significantly higherin the MCP vein than in the MCP artery. The vasoconstrictor potency of ET-1 and the thromboxane A, mimetic U-46619 were similar in the MCP vein and artery, but the maximal contraction induced by ET-1 and U-46619 was significantly higher in the MCP vein than in the MCP artery. On the other hand, theMCP vein was less sensitive than the MCP artery to the relaxation effect of nitroglycerin, nifedipine, and Lidocaine. These differences between the human MCP artery and vein in response to vasoactive agents lend support to the clinical impression in flap surgery that veins appear to be more susceptible to vasospasm than arteries and venous vasospasm seems to be more difficult to resolve than arterial vasospasm in cutaneous and musculocutaneous flap surgery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 09:35:05