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Titolo:
Antibiotic resistance in Gram-positive cocci
Autore:
Jeljaszewicz, J; Mlynarczyk, G; Mlynarczyk, A;
Indirizzi:
Med Univ Warsaw, Natl Inst Hyg, PL-00791 Warsaw, Poland Med Univ Warsaw Warsaw Poland PL-00791 Inst Hyg, PL-00791 Warsaw, Poland Med Univ Warsaw, Dept Med Microbiol, PL-00791 Warsaw, Poland Med Univ Warsaw Warsaw Poland PL-00791 icrobiol, PL-00791 Warsaw, Poland
Titolo Testata:
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
fascicolo: 4, volume: 16, anno: 2000,
pagine: 473 - 478
SICI:
0924-8579(200012)16:4<473:ARIGC>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
PENICILLIN-BINDING PROTEIN-4; D-LACTATE DEHYDROGENASE; STAPHYLOCOCCUS-AUREUS; GLYCOPEPTIDE RESISTANCE; METHICILLIN RESISTANCE; ENTEROCOCCUS-FAECALIS; VANCOMYCIN RESISTANCE; FAECIUM BM4339; GENE; TEICOPLANIN;
Keywords:
Staphylococcus; MRSA; Enterococcus; glycopeptides;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Jeljaszewicz, J Med Univ Warsaw, Natl Inst Hyg, 24 Chocinska, PL-00791 Warsaw, Poland Med Univ Warsaw 24 Chocinska Warsaw Poland PL-00791 oland
Citazione:
J. Jeljaszewicz et al., "Antibiotic resistance in Gram-positive cocci", INT J ANT A, 16(4), 2000, pp. 473-478

Abstract

Gram-positive cocci still predominate as a cause of nosocomial- and community-acquired infections. These organisms frequently reveal a high natural, intrinsic resistance to antimicrobials. Additionally, these bacteria are able to acquire resistance to frequently used drugs rapidly through selectivepressure of the environment and via the genetic evolution of bacteria. Thewide application of antimicrobials in medical and veterinary practice, usage of antibiotics in agriculture and common usage of antiseptics and disinfectants result in selective pressure. The use of antibiotics directly selects resistant variants to different antibiotics or disinfectants. The same genetic element (e.g. qac or smr) conferring resistance to some disinfectants are often present on the same plasmid conferring resistance to antibiotics. Selection of resistant variants occurs most frequently in the hospital environment. Staphylococcus aureus and enterococci are the most commonly isolated bacteria causing nosocomial infections. Among those giving therapeutic problems are methicillin-resistant staphylococci and vancomycin-resistantenterococci. Resistance to high levels of aminoglycosides or penicillins among hospital enterococcal strains can completely abolish synergism of the drugs. In these cases glycopeptides will be the drugs of choice in the treatment of serious infections. Recently S. aureus strains with decreased susceptibility to vancomycin has appeared. A mechanism for this elevated resistance, although intensively investigated, still remains unknown. (C) 2000 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 15:46:10