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Titolo:
Gemifloxacin and ciprofloxacin pharmacodynamics in an in-vitro dynamic model: prediction of the equivalent AUC/MIC breakpoints and doses
Autore:
Firsov, AA; Zinner, SH; Lubenko, IY; Vostrov, SN;
Indirizzi:
Ctr Sci & Technol LekBioTek, Dept Pharmacokinet, Moscow 117246, Russia CtrSci & Technol LekBioTek Moscow Russia 117246 , Moscow 117246, Russia Mt Auburn Hosp, Dept Med, Cambridge, MA 02238 USA Mt Auburn Hosp Cambridge MA USA 02238 , Dept Med, Cambridge, MA 02238 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
fascicolo: 4, volume: 16, anno: 2000,
pagine: 407 - 414
SICI:
0924-8579(200012)16:4<407:GACPIA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
TROVAFLOXACIN; FLUOROQUINOLONE; PHARMACOKINETICS; QUINOLONES; AREA;
Keywords:
gemifloxacin; ciprofloxacin; pharmacodynamics; in vitro models;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Firsov, AA Ctr Sci & Technol LekBioTek, Dept Pharmacokinet, 8 Nauchny Proezd, Moscow 117246, Russia Ctr Sci & Technol LekBioTek 8 Nauchny Proezd Moscow Russia 117246
Citazione:
A.A. Firsov et al., "Gemifloxacin and ciprofloxacin pharmacodynamics in an in-vitro dynamic model: prediction of the equivalent AUC/MIC breakpoints and doses", INT J ANT A, 16(4), 2000, pp. 407-414

Abstract

To compare the antimicrobial effects (AMEs) of gemifloxacin (GEM) and ciprofloxacin (CIP) on Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa, a series of pharmacokinetic profiles of GEM (a single dose withthe half-life (T-1/2) of 7.4 h and CIP (two 12 h doses with T-1/2 Of 4 h) were simulated in vitro over eight-fold ranges of the AUC/MIC ratio. Species-and strain-independent linear relationships observed between the intensity of AME (I-E) and log AUC/MIC were not superimposed for GEM and CIP (r(2) = 0.99 and 0.98, respectively). The predicted ratio for GEM that might be equivalent to a clinically established breakpoint value of AUC/MIC = 125 (mgh/l)/(mg/l) for CIP was estimated at 110 (mg h/l)/(mg/l). It was calculated, that a daily dose of CIP that might provide the same AME as a clinical dose of CEM (320 mg) on a hypothetical strain of S. aureus with MICs = MIC(50)s would be as high as 2 x 3200 mg. (C) 2000 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 15:51:09