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Titolo:
LPS induces direct death of IFN-gamma primed murine embryonic hepatocyte, BNL CL2 cells in a TNF-alpha independent manner
Autore:
So, HS; Jung, BH; Yeum, SS; Park, JS; Kim, MS; Lee, JH; Chung, SY; Choi, S; Chae, HJ; Kim, HR; Ko, CB; Chung, HT; Park, R;
Indirizzi:
Wonkwang Univ, Sch Med, Dept Microbiol, Iksan 570749, Chonbuk, South KoreaWonkwang Univ Iksan Chonbuk South Korea 570749 0749, Chonbuk, South Korea Wonkwang Univ, Sch Med, Profess Grad Sch Oriental Med, Iksan 570749, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 0749, Chonbuk, South Korea Chonbuk Natl Univ, Sch Med, Dept Microbiol, Chonju 560182, Chonbuk, South Korea Chonbuk Natl Univ Chonju Chonbuk South Korea 560182 Chonbuk, South Korea Chonnam Natl Univ, Sch Med, Dept Surg, Kwangju 501757, South Korea ChonnamNatl Univ Kwangju South Korea 501757 Kwangju 501757, South Korea Wonkwang Univ, Sch Dent, Dept Dent Pharmacol, Iksan 570749, Chonbuk, SouthKorea Wonkwang Univ Iksan Chonbuk South Korea 570749 70749, Chonbuk, SouthKorea
Titolo Testata:
IMMUNOLOGICAL INVESTIGATIONS
fascicolo: 4, volume: 29, anno: 2000,
pagine: 383 - 396
SICI:
0882-0139(2000)29:4<383:LIDDOI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; GALACTOSAMINE-SENSITIZED MICE; LIPOPOLYSACCHARIDE; HEPATITIS; EXPRESSION; ENDOTOXEMIA; INVOLVEMENT; APOPTOSIS; RECEPTOR; INJURY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: So, HS Wonkwang Univ, Sch Med, Dept Microbiol, Iksan 570749, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 honbuk, South Korea
Citazione:
H.S. So et al., "LPS induces direct death of IFN-gamma primed murine embryonic hepatocyte, BNL CL2 cells in a TNF-alpha independent manner", IMMUNOL INV, 29(4), 2000, pp. 383-396

Abstract

Although it has been well known that the role of LPS on liver damage is mediated through TNF-alpha, the mechanism by which LPS modulates the cytotoxicity of IFN-gamma on hepatocytes has not yet been clearly demonstrated. Here, we demonstrate that IFN-gamma mediated apoptosis in murine embryonic hepatocyte BNL CL2 cells is potentiated by the addition of LPS (0.5 mug/ml). Consistently, LPS markedly increases the catalytic activity of caspase 3-like protease but not caspase 1-like protease in IFN-gamma treated cells. In addition, TNF-alpha alone does not affect cell viability but rather it potentiates the cytotoxic effect of IFN-gamma on BNL CL2 cells. However, the cell viability of IFN-gamma /LPS treated cells is affected by the addition of polymyxin B but not by TNF binding protein I (TNF-BPI). These data suggest that the lipid moiety of LPS may mediate direct cytotoxicity of BNL CL2 cells in a TNF-alpha independent manner.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:55:40