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Titolo:
Antiproliferative effect and cell cycle modulation by melatonin on GH(3) cells
Autore:
Fornas, O; Mato, ME; Webb, SM;
Indirizzi:
Autonomous Univ Barcelona, Hosp St Pau, Res Inst, Dept Endocrinol,Expt Endocrinol Lab, E-08025 Barcelona, Spain Autonomous Univ Barcelona BarcelonaSpain E-08025 08025 Barcelona, Spain
Titolo Testata:
HORMONE RESEARCH
fascicolo: 5, volume: 53, anno: 2000,
pagine: 251 - 255
SICI:
0301-0163(2000)53:5<251:AEACCM>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
P53; PROLIFERATION; MCF-7;
Keywords:
GH(3); proliferation; melatonin; proliferation cell nuclear antigen; Ki67; c-myc; c-jun; p53;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Webb, SM Autonomous Univ Barcelona, Hosp St Pau, Res Inst, Dept Endocrinol,Expt Endocrinol Lab, C Sant Antoni Ma Claret 167, E-08025 Barcelona, SpainAutonomous Univ Barcelona C Sant Antoni Ma Claret 167 Barcelona Spain E-08025
Citazione:
O. Fornas et al., "Antiproliferative effect and cell cycle modulation by melatonin on GH(3) cells", HORMONE RES, 53(5), 2000, pp. 251-255

Abstract

We have investigated the effect of melatonin on cell proliferation and modulation, in the GH(3) experimental rat pituitary cell line; the expression of oncogenes c-myc, c-jun and the tumor suppressor gene p53 were also analyzed basally and after exposure to melatonin (10(-6), 10(-8) and 10(-10) M). Melatonin exhibited an antiproliferative effect at all the doses tested, decreasing the proliferating index by 50%, After exposure to melatonin, a decrease in Ki67 and Proliferation cell nuclear antigen occurred acute- and transiently (at 2 h) after a single dose which recovered at 4 h, as well as chronically after repeated 12-hour doses which persisted at 48 h; a similarbehavior was observed both acute- and chronically for c-myc and c-jun, while it was opposite for p53, rising acute- and transiently as well as after repeated exposure. These results demonstrate that melatonin modulates the proliferation mechanisms of the GH3 cells. Copyright (C) 2000 S. Karger AG,Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 15:44:06