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Titolo:
The effects of 10 days of spaceflight on the shuttle Endeavour on predominantly fast-twitch muscles in the rat
Autore:
Kraemer, WJ; Staron, RS; Gordon, SE; Volek, JS; Koziris, LP; Duncan, ND; Nindl, BC; Gomez, AL; Marx, JO; Fry, AC; Murray, JD;
Indirizzi:
Ball State Univ, Human Performance Lab, Muncie, IN 47306 USA Ball State Univ Muncie IN USA 47306 Performance Lab, Muncie, IN 47306 USA Indiana Univ, Sch Med, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 ch Med, Indianapolis, IN 46202 USA Penn State Univ, Ctr Cell Res, Lab Sports Med, University Pk, PA 16802 USAPenn State Univ University Pk PA USA 16802 d, University Pk, PA 16802 USA Ohio Univ, Coll Osteopath Med, Dept Biomed Sci, Athens, OH 45701 USA Ohio Univ Athens OH USA 45701 Med, Dept Biomed Sci, Athens, OH 45701 USA
Titolo Testata:
HISTOCHEMISTRY AND CELL BIOLOGY
fascicolo: 5, volume: 114, anno: 2000,
pagine: 349 - 355
SICI:
0948-6143(200011)114:5<349:TEO1DO>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEAVY-CHAIN EXPRESSION; RODENT SKELETAL-MUSCLE; SOLEUS MUSCLE; HINDLIMB SUSPENSION; MESSENGER-RNA; PROTEIN-SYNTHESIS; ZERO-GRAVITY; FIBER TYPES; MYOSIN; ISOFORM;
Keywords:
atrophy; cross sectional area; qualitative histochemistry; microgravity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Kraemer, WJ Ball State Univ, Human Performance Lab, Muncie, IN 47306 USA Ball State Univ Muncie IN USA 47306 Lab, Muncie, IN 47306 USA
Citazione:
W.J. Kraemer et al., "The effects of 10 days of spaceflight on the shuttle Endeavour on predominantly fast-twitch muscles in the rat", HISTOCHEM C, 114(5), 2000, pp. 349-355

Abstract

The primary purpose of this investigation was to determine the effects of microgravity on muscle fibers of the predominantly fast-twitch muscles in the rat. Cross sectional area and myosin heavy chain (MHC) composition were assessed in order to establish the acute effects of microgravity associatedwith spaceflight. The extensor digitorum longus (EDL) and gastrocnemius muscles were removed from 12 male Fisher 344 rats which had undergone 10 daysof spaceflight aboard the space shuttle Endeavour and from 12 age- and weight-matched control animals. Both groups of animals received similar amounts of food and water and were synchronized for photoperiods, environmental temperature, and humidity. Significant (P<0.05) reductions in muscle fiber size were observed in the gastrocnemius (fiber types I, IIA, IIDB, and IIB) and EDL (fiber type LIE) muscles after spaceflight. Significant MHC isoformtransformations also resulted during this brief period of microgravity exposure with a significant decrease in MHC IId isoform in the EDL muscle. A significant decrease was also observed in the MHC lid isoform in the superficial (white) component of the gastrocnemius muscle after spaceflight, although no alterations in MHC profile were demonstrated in the deep (red) component of this muscle. These findings highlight the rapid plasticity of skeletal muscle during short-term spaceflight, If such pronounced adaptations tospaceflight also occur in humans, then astronauts are likely to suffer severe decrements in skeletal muscle performance with long-term space flight and upon return to earth after both short- and long-term missions. Thus, countermeasures aimed at slowing or even preventing muscle fiber atrophy are warranted.

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Documento generato il 29/10/20 alle ore 21:08:22