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Titolo:
The VMAT2 gene in mice and humans: amphetamine responses, locomotion, cardiac arrhythmias, aging, and vulnerability to dopaminergic toxins
Autore:
Uhl, GR; Li, S; Takahashi, N; Itokawa, K; Lin, ZC; Hazama, M; Sora, I;
Indirizzi:
NIDA, Mol Neurobiol Branch, IRP, NIH, Baltimore, MD 21224 USA NIDA Baltimore MD USA 21224 iol Branch, IRP, NIH, Baltimore, MD 21224 USA
Titolo Testata:
FASEB JOURNAL
fascicolo: 15, volume: 14, anno: 2000,
pagine: 2459 - 2465
SICI:
0892-6638(200012)14:15<2459:TVGIMA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
VESICULAR MONOAMINE TRANSPORTER-2; CHROMAFFIN GRANULES; MOLECULAR-CLONING; KNOCKOUT MICE; COCAINE; ADDICTION; TOXICITY; DEATH;
Keywords:
VMAT2; serotonin; histamine; dopamine; norepinephrine; synaptic vesicle; Parkinsonism; MPTP;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Uhl, GR NIDA, Mol Neurobiol Branch, IRP, NIH, Rm 302,5500 Nathan Shock Dr,Baltimore, MD 21224 USA NIDA Rm 302,5500 Nathan Shock Dr Baltimore MD USA 21224 21224 USA
Citazione:
G.R. Uhl et al., "The VMAT2 gene in mice and humans: amphetamine responses, locomotion, cardiac arrhythmias, aging, and vulnerability to dopaminergic toxins", FASEB J, 14(15), 2000, pp. 2459-2465

Abstract

Monoamine compartmentalization in monoaminergic neurons uses serial actionof the plasma membrane and vesicular monoamine (VAMT2) transporters. We can now define the sequences of the genes encoding these transporters in miceand humans, examine influences of deletions of this gene and alteration inits expression levels in transgenic mice, and identify sequence polymorphisms in the human VMAT2 gene. Examination of VMAT2 variants can provide potential insights into roles for allelic variants at these loci in variant drug responses and in diseases linked to monoaminergic systems, including substance abuse and Parkinson's disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 13:11:51