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Titolo:
Clinical experience with intraurethral alprostadil (MUSE (R)) in the treatment of men with erectile dysfunction - A retrospective study
Autore:
Guay, AY; Perez, JB; Velasquez, E; Newton, RA; Jacobson, JP;
Indirizzi:
Lahey Clin Northshore, Ctr Sexual Funct, Peabody, MA 01960 USA Lahey Clin Northshore Peabody MA USA 01960 l Funct, Peabody, MA 01960 USA Lahey Clin Northshore, Sect Endocrinol, Peabody, MA 01960 USA Lahey Clin Northshore Peabody MA USA 01960 ocrinol, Peabody, MA 01960 USA Lahey Clin Northshore, Dept Urol, Peabody, MA 01960 USA Lahey Clin Northshore Peabody MA USA 01960 pt Urol, Peabody, MA 01960 USA Lahey Clin Northshore, Biostat Sect, Peabody, MA 01960 USA Lahey Clin Northshore Peabody MA USA 01960 at Sect, Peabody, MA 01960 USA
Titolo Testata:
EUROPEAN UROLOGY
fascicolo: 6, volume: 38, anno: 2000,
pagine: 671 - 676
SICI:
0302-2838(200012)38:6<671:CEWIA(>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACAVERNOUS INJECTION THERAPY; TRANSURETHRAL ALPROSTADIL; PROSTAGLANDIN E(1); SELF-INJECTION; DOUBLE-BLIND; PAPAVERINE; PHENTOLAMINE; SILDENAFIL; EFFICACY; MIXTURE;
Keywords:
prostaglandin; alprostadil; erectile dysfunction; sexual dysfunction; MUSE therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Guay, AY Lahey Clin Northshore, Ctr Sexual Funct, 1 Essex Ctr Dr, Peabody,MA 01960USA Lahey Clin Northshore 1 Essex Ctr Dr Peabody MA USA 01960 1960USA
Citazione:
A.Y. Guay et al., "Clinical experience with intraurethral alprostadil (MUSE (R)) in the treatment of men with erectile dysfunction - A retrospective study", EUR UROL, 38(6), 2000, pp. 671-676

Abstract

Objective: The Food and Drug Administration (USA) approved the transurethral administration of prostaglandin (alprostadil in January 1997), which hadan efficacy of approximately 50% in clinical trials. We studied its effectiveness in clinical practice. Methods: Patient and partner education was followed by an initial office trial of a medicated urethral system for erection (MUSE(R)) after other medical risk factors were corrected during a 2- to 4-month period. The initial titration dose of alprostadil was usually 125 or 250 mug. Further titration, if needed, was instituted by the patient at home. Success was determined as the satisfactory completion of sexual intercourse in more than 66% of attempts, with a minimum of two being required. Results: Two hundred and seventy patients entered the trials, and follow-up information was available in 229 (85%). The overall success rate was 56%. The dose required was 500 mug in 49.2% and 1,000 mug in 42.2%. Of the 44% in whom treatment failed, 61.4% did so because of lack of efficacy and 38.6% because of side effects (genital pain or urethral bleeding). Minor urogenital symptoms, which did not interfere with treatment, occurred in an additional 40% of patients. Conclusions: The efficacy of transurethral administration of alprostadil (56%) is higher than the initial published clinical trial data and higher than recent reported clinical experiences, although higher doses were required in our study. Men over 50 years of age, having an organic cause for erectile dysfunction, had better responses. Patient and partner education is important for successful treatment, and the in-office initial titration is an integral part of this success. Prior correction of medical risk factors mayenhance the success rate. Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:29:47