Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Pretreatment with diazepam suppresses the reduction in defensive freezing behavior induced by fluvoxamine in the conditioned fear stress paradigm in mice
Autore:
Miyamoto, J; Tsuji, M; Takeda, H; Nawa, H; Matsumiya, T;
Indirizzi:
Tokyo Med Univ, Dept Pharmacol, Shinjuku Ku, Tokyo 1608402, Japan Tokyo Med Univ Tokyo Japan 1608402 ol, Shinjuku Ku, Tokyo 1608402, Japan Tokyo Med Univ, Intractable Dis Res Ctr, Shinjuku Ku, Tokyo 1608402, JapanTokyo Med Univ Tokyo Japan 1608402 tr, Shinjuku Ku, Tokyo 1608402, Japan
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 409, anno: 2000,
pagine: 81 - 84
SICI:
0014-2999(200012)409:1<81:PWDSTR>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN REUPTAKE INHIBITORS; FORCED SWIMMING TEST; SOCIAL PHOBIA; DOUBLE-BLIND; BENZODIAZEPINES; FLUOXETINE; RATS;
Keywords:
fluvoxamine; diazepam; anxiety; conditioned fear stress; defensive freezing behavior; (mouse);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Takeda, H Tokyo Med Univ, Dept Pharmacol, Shinjuku Ku, 6-1-1 Shinjuku, Tokyo 1608402, Japan Tokyo Med Univ 6-1-1 Shinjuku Tokyo Japan 1608402 608402, Japan
Citazione:
J. Miyamoto et al., "Pretreatment with diazepam suppresses the reduction in defensive freezing behavior induced by fluvoxamine in the conditioned fear stress paradigm in mice", EUR J PHARM, 409(1), 2000, pp. 81-84

Abstract

The effects of the selective serotonin (5-hydroxytryptamine (5-HT)) reuptake inhibitor fluvoxamine, given alone or in combination with the benzodiazepine anxiolytic diazepam on the defensive freezing behavior of mice in the conditioned fear stress paradigm were examined. Fluvoxamine (5-20 mg/kg, i.p.) induced a dose-dependent reduction in freezing behavior. In contrast, while low doses of diazepam (0.125 and 0.25 mg/kg, i.p,) reduced the freezing behavior, such effects were not observed with high doses of diazepam (0.5and 1 mg/kg, i.p.). In the combination study, fluvoxamine (20 mg/kg, i.p.)did not reduce the freezing behavior in mice that had been pretreated withdiazepam (0.125-1 mg/kg, i.p.). None of the doses of fluvoxamine and diazepam used in the present study had any effects on motor activity under non-stressed conditions. These results suggest that benzodiazepines may negatively influence the clinical efficacy of selective 5-HT reuptake inhibitors inthe treatment of anxiety disorders. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 11:28:43