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Titolo:
Interaction between glucagon and Hexarelin, a peptidyl GH secretagogue, onsomatotroph and corticotroph secretion in humans
Autore:
Arvat, E; Maccagno, B; Ramunni, J; Giordano, R; Broglio, F; Gianotti, L; Maccario, M; Camanni, F; Ghigo, E;
Indirizzi:
Molinette Mauriziano Hosp, Div Endocrinol, Dept Internal Med, I-10126 Turin, Italy Molinette Mauriziano Hosp Turin Italy I-10126 Med, I-10126 Turin, Italy
Titolo Testata:
EUROPEAN JOURNAL OF ENDOCRINOLOGY
fascicolo: 5, volume: 143, anno: 2000,
pagine: 601 - 606
SICI:
0804-4643(200011)143:5<601:IBGAHA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE-RELEASING PEPTIDE; PITUITARY-ADRENAL AXIS; GROWTH-HORMONE; (GH)-RELEASING PEPTIDE; STIMULATION-TEST; NEUROPEPTIDE-Y; I LEVELS; CORTISOL; GHRP-6; DEFICIENCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Ghigo, E Molinette Mauriziano Hosp, Div Endocrinol, Dept Internal Med, Corso Dogliotti 14, I-10126 Turin, Italy Molinette Mauriziano Hosp Corso Dogliotti 14 Turin Italy I-10126
Citazione:
E. Arvat et al., "Interaction between glucagon and Hexarelin, a peptidyl GH secretagogue, onsomatotroph and corticotroph secretion in humans", EUR J ENDOC, 143(5), 2000, pp. 601-606

Abstract

Objective: Glucagon administration stimulates both somatotroph and corticotroph secretion in humans, although this happens only if glucagon is administered by the intramuscular route and not by the intravenous route. On the other hand, GH secretagogues (GHS) strongly stimulate GH and also possess ACTH-releasing activity. Design and Methods: To clarify the mechanisms underlying the stimulatory effects of both glucagon and GHS on somatotroph and corticotroph secretion, we studied the GH, ACTH and cortisol responses to glucagon (GLU, 0.017 mg/kg i.m.) and Hexarelin, a peptidyl GHS (HM, 2.0 mug/kg i.v.) given alone or in combination In 6 normal young volunteers (females, aged 26-32 years, body mass index 19.7-22.5 kg/m(2)). Results: GLU administration elicited a clear increase in GH (peak vs baseline, mean+/-S.E.M.: 11.6 +/- 3.4 vs 3.3 +/- 0.7 mug/l, P < 0.02), ACTH (11.6 +/- 3.3 vs 4.1 +/- 0.3 pmol/l, P < 0.02) acid cortisol (613.5 +/- 65.6 vs436.9 +/- 13.3 nmol/l, P < 0.05) levels. HEX induced a marked increase in GH levels (55.7 +/- 19.8 vs 3.7 +/- 1.9 <mu>g/l P < 0.005) and also significant ACTH (5.7 +/- 1.1 vs 3.4 +/- 0.6 pmol/l, P < 0.01) and cortisol (400.2+/- 31.4 vs 363.4 +/- 32.2 nmol/l, P < 0.05) responses. The GH area under the curve (AUC) after HEX was clearly higher than after GLU (1637.3 +/- 494.0 vs 479.1 +/- 115.7 <mu>g/1/120 min, P < 0.04) while HEX and GLU coadministration had a true synergistic effect on GH release (3243.8 +/- 687.5 <mu>g/1/120 min, P < 0.02). The ACTH and cortisol AUCs after HEX were lower (P < 0.02) than those after GLU (208.3 +/- 41.3 vs 426.3 +/- 80.9 pmol/l/120 min and 18 874.5 +/- 1626.1 vs 28 338.5 +/- 2430.7 nmol/1/120min respectively). The combined administration of HEX and GLU had an effect which was lessthan additive on both ACTH (564.02 +/- 76.5 pmol/l/120 min) and cortisol (35424.6 +/- 5548.1 nmol/l/120 min) secretion. Conclusions: These results show that the intramuscular administration of glucagon releases less GH but more ACTH and cortisol than Hexarelin. The combined administration of glucagon and Hexarelin has a true synergistic effect on somatotroph secretion but a less than additive effect on corticotroph secretion; these findings suggest that these stimuli act via different mechanisms to stimulate somatotrophs while they could have a common action on the hypothalamo-pituitary adrenal axis.

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Documento generato il 07/07/20 alle ore 12:33:23