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Titolo:
Cost-effectiveness analysis of interferon as adjuvant therapy in high-riskmelanoma patients in Spain
Autore:
Gonzalez-Larriba, JL; Serrano, S; Alvarez-Mon, M; Camacho, F; Casado, MA; Diaz-Perez, JL; Diaz-Rubio, E; Fosbrook, L; Guillem, V; Lopez-Lopez, JJ; Moreno-Nogueira, JA; Toribio, J;
Indirizzi:
Hosp Clin San Carlos, Dept Med Oncol, Madrid 28040, Spain Hosp Clin San Carlos Madrid Spain 28040 t Med Oncol, Madrid 28040, Spain Univ Granada, Hosp San Cecilio, Dept Dermatol, Granada, Spain Univ Granada Granada Spain p San Cecilio, Dept Dermatol, Granada, Spain Hosp Principe Asturias, Dept Internal Med, Alcala De Henares, Spain Hosp Principe Asturias Alcala De Henares Spain Alcala De Henares, Spain Hosp Virgen Macarena, Dept Dermatol, Seville, Spain Hosp Virgen Macarena Seville Spain arena, Dept Dermatol, Seville, Spain Schering Plough SA, Madrid, Spain Schering Plough SA Madrid SpainSchering Plough SA, Madrid, Spain Hosp Cruces, Dept Dermatol, Baracaldo, Spain Hosp Cruces Baracaldo Spain osp Cruces, Dept Dermatol, Baracaldo, Spain Inst Valenciano Oncol, Dept Med Oncol, Valencia, Spain Inst Valenciano Oncol Valencia Spain l, Dept Med Oncol, Valencia, Spain Hosp Santa Cruz & San Pablo, Dept Med Oncol, E-08025 Barcelona, Spain HospSanta Cruz & San Pablo Barcelona Spain E-08025 025 Barcelona, Spain Hosp Univ Virgen Rocio, Dept Med Oncol, Seville, Spain Hosp Univ Virgen Rocio Seville Spain io, Dept Med Oncol, Seville, Spain Hosp Gen Calicia Gil Casares, Dept Dermatol, Santiago De Compostela, SpainHosp Gen Calicia Gil Casares Santiago De Compostela Spain ostela, Spain
Titolo Testata:
EUROPEAN JOURNAL OF CANCER
fascicolo: 18, volume: 36, anno: 2000,
pagine: 2344 - 2352
SICI:
0959-8049(200012)36:18<2344:CAOIAA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESECTED CUTANEOUS MELANOMA; COOPERATIVE-ONCOLOGY-GROUP; RENAL REPLACEMENT THERAPY; MALIGNANT-MELANOMA; ECONOMIC-ANALYSIS; ALFA-2B; TRIAL; CARE; GUIDELINES; QUALITY;
Keywords:
interferon; cost-effectiveness; melanoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Gonzalez-Larriba, JL Hosp Clin San Carlos, Dept Med Oncol, Madrid 28040, Spain Hosp Clin San Carlos Madrid Spain 28040 8040, Spain
Citazione:
J.L. Gonzalez-Larriba et al., "Cost-effectiveness analysis of interferon as adjuvant therapy in high-riskmelanoma patients in Spain", EUR J CANC, 36(18), 2000, pp. 2344-2352

Abstract

In the randomised clinical trial E1684, the administration of interferon (IFN) alpha-2b resulted in prolonged disease-free and overall survival in high-risk melanoma patients following surgical resection. However, and considering the cost and toxicity of IFN, the convenience of its widespread use should be evaluated. The aim of this study was to analyse the cost-effectiveness ratio of adjuvant therapy with IFN alpha-2b in melanoma patients versus an untreated control group. A Markov model was used to compare two hypothetical cohorts of 1000 patients aged 50 years, according to the clinical outcome of the E1684 study, The cohort of patients treated with IFN alpha-2b has an increased overall survival of 1.90 years during the patient's lifetime. The incremental discounted cost per life year gained of IFN versus observation is 9015 Euros according to the projection generated by the model. The sensitivity analysis demonstrated that changes in the most relevant study end-points do not modify the study outcome. In conclusion, in high-risk melanoma patients following surgical resection, the cost-effectiveness of IFN alpha-2b (at a dose of 20 MU/m(2)/day, 5 days per week for one month, followed by 10 MU/m(2) TIW, up to one complete year of therapy) versus an untreated control group is within the limits established in health economics todetermine if adoption of a new treatment is economically justified and is comparable with other interventions in which cost-effectiveness is acceptable to the National Health System. (C) 2000 Elsevier Science Ltd. All rightsreserved.

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Documento generato il 20/01/20 alle ore 10:17:44